SynthesisPloS one2015
Predictive Value of C-Reactive Protein for Major Complications after Major Abdominal Surgery: A Systematic Review and Pooled-Analysis.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Impact of laparoscopic versus open surgery on humoral immunity in patients with colorectal cancer: a systematic review and meta-analysis.Surgical endoscopy · 2024Pooled it
- Operative management of acute abdomen after bariatric surgery in the emergency setting: the OBA guidelines.World journal of emergency surgery : WJES · 2022Guideline
- Diagnostic accuracy of procalcitonin and interleukin-6 for postoperative infection in major gastrointestinal surgery: a systematic review and meta-analysis.Annals of the Royal College of Surgeons of England · 2022Pooled it
- A Systematic Review and Meta-analysis of Physical Exercise Prehabilitation in Major Abdominal Surgery (PROSPERO 2017 CRD42017080366).Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Pooled it
- Pooled it
- Effects of prucalopride succinate on postoperative bowel motility and inflammation following minimally invasive gastrectomy.Scientific reports · 2026Trial
- C-reactive protein in predicting major postoperative complications are there differences in open and minimally invasive colorectal surgery? Substudy from a randomized clinical trial.Surgical endoscopy · 2018Trial
- Development of the Novel G-CMAP Score: A Preoperative Scoring System for Predicting Postoperative Complications After Gastrectomy for Gastric Cancer.Annals of surgical oncology · 2026Article
- Development and validation of an interpretable machine learning model for predicting postoperative complications after transanal total mesorectal excision: a multicenter study.Techniques in coloproctology · 2026Article
- A biomarker-integrated nomogram for predicting postoperative pancreatic fistula in low- to intermediate-risk patients after pancreaticoduodenectomy.Journal of gastrointestinal oncology · 2026Article
- Development of a risk prediction model for adhesive intestinal obstruction following laparoscopic surgery for acute appendicitis based on clinical characteristics and laboratory indicators.Frontiers in medicine · 2026Article
- Value of Serum C-Reactive Protein (CRP) Level in Early Detection of Anastomotic Leakage following Salvage Esophagectomy after Definitive Chemoradiation for Esophageal Squamous Cell Carcinoma.South Asian journal of cancer · 2025Article
- Identification of postoperative complications in sigmoid colon cancer and rectal cancer using the C-reactive protein level.Surgical endoscopy · 2025Article
- Impact of alcohol consumption on outcomes and potential of immune biomarkers for postoperative complications in trauma patients.Frontiers in immunology · 2025Article
- The Effects of Seasonal Variation on the Outcomes of Patients Undergoing Off-Pump Coronary Artery Bypass Grafting.Reviews in cardiovascular medicine · 2024Article
- Early warning model to detect anastomotic leakage following colon surgery: a clinical observational study.Annals of coloproctology · 2024Article
- Procalcitonin and C-reactive protein as early markers of anastomotic leakage in intestinal resections for advanced ovarian cancer (EDMOCS).Acta obstetricia et gynecologica Scandinavica · 2024Observational
- The value of C-reactive protein, leucocytes and vital signs in detecting major complications after oncological colorectal surgery.Langenbeck's archives of surgery · 2024Article
- Dynamics of C-reactive protein level after orthopedic surgeries.Journal of orthopaedics · 2024Article
- COVID-19 and myocardial injury: Targeting elevated biomarkers for potential novel therapies.Clinics (Sao Paulo, Brazil) · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly diagnosis and treatment of complications after major abdominal surgery can decrease associated morbidity and mortality. Postoperative CRP levels have shown a strong correlation with complications. Aim of this systematic review and pooled-analysis was to assess postoperative values of CRP as a marker for major complications and construct a prediction model. STUDY
designA systematic review was performed for CRP levels as a predictor for complications after major abdominal surgery (MAS). Raw data was obtained from seven studies, including 1427 patients. A logit regression model assessed the probability of major complications as a function of CRP levels on the third postoperative day. Two practical cut-offs are proposed: an optimal cut-off for safe discharge in a fast track protocol and another for early identification of patients with increased risk for major complications.
resultsA prediction model was calculated for major complications as a function of CRP levels on the third postoperative day. Based on the model several cut-offs for CRP are proposed. For instance, a two cut-off system may be applied, consisting of a safe discharge criterion with CRP levels below 75 mg/L, with a negative predictive value of 97.2%. A second cut-off is set at 215 mg/L (probability 20%) and serves as a predictor of complications, indicating additional CT-scan imaging.
conclusionsThe present study provides insight in the interpretation of CRP levels after major abdominal surgery, proposing a prediction model for major complications as a function of CRP on postoperative day 3. Cut-offs for CRP may be implemented for safe early-discharge in a fast-track protocol and, secondly as a threshold for additional examinations, such as CT-scan imaging, even in absence of clinical signs, to confirm or exclude major complications. The prediction model allows for setting a cut-off at the discretion of individual surgeons or surgical departments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.