Evidence map›Paper›PMID 26177523›Full record

ReviewCurrent opinion in immunology2015

Viral manipulation of the host immune response.

Allison Christiaansen, Steven M Varga, Juliet V Spencer

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Current issues in molecular biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Editorial: Genetic and molecular markers in human viral infections.Frontiers in cellular and infection microbiology · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Possible Trace of HTLV-1 Virus in Modulation of Cbl-b, ITCH, and PP2A Suppressor Genes.International journal of molecular and cellular medicine · 2025
    Article
  13. Article
  14. Association of donor hepatitis C virus infection status and risk of BK polyomavirus viremia after kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Allison ChristiaansenDepartment of Microbiology, The University of Iowa, 51 Newton Road, 3-532 Bowen Science Building, Iowa City, IA 52242, USA.
Steven M VargaDepartment of Microbiology, The University of Iowa, 51 Newton Road, 3-532 Bowen Science Building, Iowa City, IA 52242, USA; Department of Pathology, The University of Iowa, 51 Newton Road, 3-532 Bowen Science Building, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology, The University of Iowa, 51 Newton Road, 3-532 Bowen Science Building, Iowa City, IA 52242, USA.
Juliet V SpencerDepartment of Biology, University of San Francisco, Harney Science Center, 2130 Fulton Street, San Francisco, CA 94117, USA. Electronic address: jspencer@usfca.edu.

Funding

Training in Molecular Virology, Viral Pathogenesis and Viral VectorsT32AI007533 · NIAID · UNIVERSITY OF IOWA · PI Stanley Perlman · 1998 to 2026
$2.5M
Modification of Host Chemokine Responses by Human CytomegalovirusR15AI111232 · NIAID · UNIVERSITY OF SAN FRANCISCO · PI SPENCER, JULIET VESCIO · 2014 to 2014
$425k
NIAID NIH HHS AI111232NIAID NIH HHS R15 AI111232NIAID NIH HHS T32 AI007533
6 · The paper itself

Abstract

Viruses are obligate intracellular parasites that require a host for essential machinery to replicate and ultimately be transmitted to new susceptible hosts. At the same time, the immune system has evolved to protect the human body from invasion by viruses and other pathogens. To counter this, viruses have developed an arsenal of strategies to not only avoid immune detection but to actively manipulate host immune responses to create an environment more favorable for infection. Here, we describe recent advances uncovering novel mechanisms by which viruses skew host immune responses through modulation of cytokine and chemokine signaling networks, interference with antigen presentation and T cell responses, and preventing antibody production.

Indexed as

Host-Pathogen InteractionsImmunityVirus Physiological PhenomenaAnimalsB-Lymphocyte SubsetsCytokinesHumansImmunomodulationInflammation MediatorsSignal TransductionT-Lymphocyte SubsetsVirus DiseasesCytokinesInflammation Mediators

Identifiers

PMID26177523
PMCPMC4593765

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.