ArticlePloS one2015
Anthelmintic Effect of Biocompatible Zinc Oxide Nanoparticles (ZnO NPs) on Gigantocotyle explanatum, a Neglected Parasite of Indian Water Buffalo.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Nanotechnology-based strategies for helminth control: drug delivery, green nanoparticles, mechanisms, and translational barriers.Discover nano · 2026Review
- Effect of Zinc Oxide Nanoparticles From Infant Formula Milk Powder on Colon Cells In Vitro.Journal of applied toxicology : JAT · 2026Article
- Assessment of oxidative stress biomarkers in liver flukeVeterinary research forum : an international quarterly journal · 2026Article
- An automated platform for "on-demand" high-speed catalyst synthesis by flame spray pyrolysis.Digital discovery · 2025Article
- Promising therapeutic efficacy of nitazoxanide-loaded zinc oxide nano-formula against intestinal and muscular phases of experimental trichinellosis.PLoS neglected tropical diseases · 2025Article
- In Vitro Effects of Vanadate Erbium/Silver Oxide (ErVOVeterinary medicine and science · 2025Article
- Evaluating the In Vitro Anthelmintic Activity of Zinc Oxide Nanoparticles (ZnO-NPs) Against the Adult Stages of Fasciola hepatica.Veterinary medicine and science · 2025Article
- Facile Synthesis of Polypyrrole-Decorated RGO-CuS Nanocomposite for Efficient Nickel Removal from Wastewater.Polymers · 2024Article
- From e-waste to eco-sensors: synthesis of reduced graphene oxide/ZnO from discarded batteries for a rapid electrochemical bisphenol A sensor.RSC advances · 2024Article
- Anthelmintic effects of some medicinal plants on different life stages of Fasciola hepatica: Evidence on oxidative stress biomarkers, and DNA damage.PLoS neglected tropical diseases · 2024Article
- In vitro assessment of the anthelmintic activity of copper oxide and zinc oxide nanoparticles on egg and adult stages of Fasciola hepatica: evidence on oxidative stress biomarkers, and DNA damage.BMC veterinary research · 2024Article
- Article
- In vivo efficacy of silver nanoparticles againstJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- Exploring the antibacterial and dermatitis-mitigating properties of chicken egg white-synthesized zinc oxide nano whiskers.Frontiers in cellular and infection microbiology · 2023Article
- Article
- Development of Ag-ZnO/AgO Nanocomposites Effectives forPharmaceutics · 2022Article
- Current Research on Zinc Oxide Nanoparticles: Synthesis, Characterization, and Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2022Review
- Advances in diagnosis and control of anthelmintic resistant gastrointestinal helminths infecting ruminants.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Review
- Endoplasmic Reticulum Stress Provocation by Different Nanoparticles: An Innovative Approach to Manage the Cancer and Other Common Diseases.Molecules (Basel, Switzerland) · 2020Review
- Zinc oxide nanoparticles and L-carnitine effects on neuro-schistosomiasis mansoni induced in mice.Environmental science and pollution research international · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helminth parasites of veterinary importance cause huge revenue losses to agrarian economy worldwide. With the emergence of drug resistance against the current formulations, there is a need to focus on the alternative approaches in order to control this menace. In the present study, biocompatible zinc oxide nanoparticles (ZnO NPs) were used to see their in vitro effect on the biliary amphistomes, Gigantocotyle explanatum, infecting Bubalus bubalis because these nanoparticles are involved in generation of free radicals that induce oxidative stress, resulting in disruption of cellular machinery. The ZnO NPs were synthesized by using egg albumin as a biotemplate and subsequently characterized by Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), X-ray Diffraction and Spectrophotometrical, which showed that ZnO NPs were highly purified wurtzite type polycrystals, with a mean size of 16.7 nm. When the parasites were treated with lower concentrations (0.004% and 0.008%) of the ZnO NPs, the worms mounted a protective response by stimulating the antioxidant system but the treatment of G. explanatum with 0.012% ZnO NPs produced significant inhibition of the antioxidant enzymes like superoxide dismutase (SOD) (p< 0.05) and glutathione S- transferase (GST) (p<0.01), while the level of malondialdehyde (MDA), a lipid peroxidation marker, was significantly (p< 0.01) elevated. SEM and histopathology revealed pronounced tegumental damage showing the disruption of surface papillae and the annulations, particularly in the posterior region near acetabulum. The under expression of a number of polypeptides, loss of worm motility in a time dependent manner, further reflect strong anthelmintic potential of ZnO NPs. It can be concluded that the anthelmintic effect might be due to the production of reactive oxygen species that target a variety of macromolecules such as nucleic acid, protein and lipids which are involved in different cellular processes.
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