ReviewRedox biology2015
Redox implications in adipose tissue (dys)function--A new look at old acquaintances.
Review in Redox biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Osteocytes orchestrate browning: emerging signals in bone-fat crosstalk: a systematic review.Frontiers in endocrinology · 2026Pooled it
- Synergistic Effects of High-Intensity Interval Training andInternational journal of molecular sciences · 2025Trial
- Pharmacological Potential of Selenoproteins in the Regulation of Oxidative Stress in Liver Diseases.Pharmaceutics · 2026Review
- Depot-dependent peroxisome response in the rat white adipose tissue under hypothyroidism.European journal of histochemistry : EJH · 2026Article
- New insights into the role of metallothioneins in obesity and diabetes.International journal of obesity (2005) · 2025Review
- Generalized Anxiety Disorder and Obesity: Overlapping Neuroendocrine, Metabolic, and Behavioral Pathways.Nutrients · 2025Review
- Multigenerational exposure to trace concentrations of DDT residues in Wistar rats: Effects on biometric development and biochemical parameters.Toxicology reports · 2025Article
- Dietary Flaxseed Oil and Its Blended Oil Alleviate High-Fat Diet-Induced Obesity in Mice by Improving Lipid Metabolism and Regulating Gut Microbiota.Foods (Basel, Switzerland) · 2025Article
- Modification of adipogenesis and oxidative stress by quercetin: positive or negative impact on adipose tissue metabolism of obese diabetic Zucker rats?Journal of physiology and biochemistry · 2025Article
- Dysregulation of HO-1-SIRT1 Axis is Associated with AngII-Induced Adipocyte Dysfunction.Journal of clinical and medical sciences · 2024Article
- Clozapine suppresses NADPH oxidase activation, counteracts cytosolic HRedox biology · 2023Article
- Thioredoxin/Glutaredoxin Systems and Gut Microbiota in NAFLD: Interplay, Mechanism, and Therapeutical Potential.Antioxidants (Basel, Switzerland) · 2023Review
- Total Antioxidant Capacity in Obese and Non-Obese Subjects and Its Association with Anthropo-Metabolic Markers: Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2023Review
- 1,3-Butanediol Administration Increases β-Hydroxybutyrate Plasma Levels and Affects Redox Homeostasis, Endoplasmic Reticulum Stress, and Adipokine Production in Rat Gonadal Adipose Tissue.Antioxidants (Basel, Switzerland) · 2023Article
- Application ofLife (Basel, Switzerland) · 2023Review
- Thermogenic Adipose Redox Mechanisms: Potential Targets for Metabolic Disease Therapies.Antioxidants (Basel, Switzerland) · 2023Review
- PTPN2 targets TAK1 for dephosphorylation to improve cellular senescence and promote adipose tissue browning in T2DM.Frontiers in pharmacology · 2023Article
- Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders.Molecular metabolism · 2022Review
- Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue.Redox biology · 2022Article
- Obesity-An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances.Biomolecules · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is an energy balance disorder associated with dyslipidemia, insulin resistance and diabetes type 2, also summarized with the term metabolic syndrome or syndrome X. Increasing evidence points to "adipocyte dysfunction", rather than fat mass accretion per se, as the key pathophysiological factor for metabolic complications in obesity. The dysfunctional fat tissue in obesity characterizes a failure to safely store metabolic substrates into existing hypertrophied adipocytes and/or into new preadipocytes recruited for differentiation. In this review we briefly summarize the potential of redox imbalance in fat tissue as an instigator of adipocyte dysfunction in obesity. We reveal the challenge of the adipose redox changes, insights in the regulation of healthy expansion of adipose tissue and its reduction, leading to glucose and lipids overflow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.