Evidence map›Paper›PMID 26177367›Full record

ArticlePloS one2015

Microarray Analysis Reveals Potential Biological Functions of Histone H2B Monoubiquitination.

You Wu, Ping Chen, Yuanya Jing, Chen Wang, Yu-Long Men, Wang Zhan, Qiang Wang, Zhixue Gan, Jin Huang, Kun Xie and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Atypical Ubiquitination and Parkinson's Disease.International journal of molecular sciences · 2022
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

You WuResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Department of Breast Surgery of Yangpu Hospital, Tongji University, Shanghai 200092, P. R. China.
Ping ChenResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Department of Breast Surgery of Yangpu Hospital, Tongji University, Shanghai 200092, P. R. China.
Yuanya JingResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Department of Breast Surgery of Yangpu Hospital, Tongji University, Shanghai 200092, P. R. China.
Chen WangResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Department of Breast Surgery of Yangpu Hospital, Tongji University, Shanghai 200092, P. R. China.
Yu-Long MenResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Department of Breast Surgery of Yangpu Hospital, Tongji University, Shanghai 200092, P. R. China.
Wang ZhanResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Department of Breast Surgery of Yangpu Hospital, Tongji University, Shanghai 200092, P. R. China.
Qiang WangDepartment of Nephrology and Rheumatology of Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200092, P. R. China.
Zhixue GanResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Department of Breast Surgery of Yangpu Hospital, Tongji University, Shanghai 200092, P. R. China.
Jin HuangResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Department of Breast Surgery of Yangpu Hospital, Tongji University, Shanghai 200092, P. R. China.
Kun XieResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Department of Breast Surgery of Yangpu Hospital, Tongji University, Shanghai 200092, P. R. China.
Jiangsheng MiDepartment of Science and Education, People's Hospital of Zunhua, Tangshan, Hebei 064200, P. R. China.
Chenghua YuDepartment of Science and Education, People's Hospital of Zunhua, Tangshan, Hebei 064200, P. R. China.
Xiuqing YuDepartment of Science and Education, People's Hospital of Zunhua, Tangshan, Hebei 064200, P. R. China.
Pei-Chao ChenCollege of Life and Environmental Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, P. R. China.
Jian-Feng ChangResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Department of Breast Surgery of Yangpu Hospital, Tongji University, Shanghai 200092, P. R. China.
Fengfeng CaiResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Department of Breast Surgery of Yangpu Hospital, Tongji University, Shanghai 200092, P. R. China.
Su ChenResearch Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Department of Breast Surgery of Yangpu Hospital, Tongji University, Shanghai 200092, P. R. China; Department of Science and Education, People's Hospital of Zunhua, Tangshan, Hebei 064200, P. R. China.
Tongji University · CNWenzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histone H2B monoubiquitination is a key histone modification that has significant effects on chromatin higher-order structure and gene transcription. Multiple biological processes have been suggested to be tightly related to the dynamics of H2B monoubiquitination. However, a comprehensive understanding of biological roles of H2B monoubiquitination is still poorly understood. In the present study, we developed an efficient tool to disrupt endogenous H2B monoubiquitination levels by using an H2BK120R mutant construct expressed in human cells. Genome-wide microarray analysis of these cells revealed a potential global view of biological functions of H2B monoubiquitination. Bioinformatics analysis of our data demonstrated that while H2B monoubiquitination expectedly affected a number of previously reported biological pathways, we also uncovered the influence of this histone modification on many novel biological processes. Therefore, our work provided valuable information for understanding the role of H2B monoubiquitination and indicated potential directions for its further studies.

Indexed as

Oligonucleotide Array Sequence AnalysisUbiquitinationAnimalsCell DifferentiationChromatinDNA DamageDNA RepairGene Expression ProfilingGene Expression RegulationGene Knockdown TechniquesHEK293 CellsHeLa CellsHistonesHumansMiceMouse Embryonic Stem CellsChromatinHistonesMutant ProteinsUbiquitin

Identifiers

PMID26177367
PMCPMC4503354
OpenAlexW1665612719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.