ArticlePain medicine (Malden, Mass.)2016
Pain Phenotypes and Associated Clinical Risk Factors Following Traumatic Amputation: Results from Veterans Integrated Pain Evaluation Research (VIPER).
Article in Pain medicine (Malden, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 94 citations in OpenAlex.
- Postoperative Imaging Characteristics of Targeted Muscle Reinnervation and Regenerative Peripheral Nerve Interfaces.Plastic and reconstructive surgery. Global open · 2026Article
- Understanding the role of diabetes mellitus on symptomatic neuroma development and identifying the ideal patient for prophylactic surgical management.Archives of orthopaedic and trauma surgery · 2026Review
- Magnetic resonance imaging appearance of targeted muscle reinnervation and regenerative peripheral nerve interfaces in oncologic amputees.Skeletal radiology · 2026Article
- Prevention of nerve growth and evoked pain with a nerve cap graft device.NPJ Regenerative medicine · 2025Article
- Targeted Muscle Reinnervation-an Up-to-Date Review: Evidence, Indications, and Technique.Archives of plastic surgery · 2025Article
- Examining patient reported outcome measures for phantom limb pain: measurement use in a sample of Veterans with amputation.Disability and rehabilitation · 2025Article
- Residual limb neuropathic pain association with neuroma, prosthetic, function, and participation outcomes in individuals living with a transtibial amputation: an exploratory study.Journal of rehabilitation medicine · 2025Article
- Treatment of Phantom and Residual Limb Pain in Amputees With Targeted Muscle Reinnervation.Eplasty · 2025Article
- Combat amputee care for Global War on Terror Veterans: A systematic review.Journal of military, veteran and family health · 2024Article
- A novel nerve isolation technique for targeted muscle reinnervation during below knee amputation.Journal of vascular surgery cases and innovative techniques · 2023Article
- [Clinical updates on phantom limb pain : German version].Schmerz (Berlin, Germany) · 2023Review
- Targeted Muscle Reinnervation for Limb Amputation to Avoid Neuroma and Phantom Limb Pain in Patients Treated at a Pediatric Hospital.Plastic and reconstructive surgery. Global open · 2023Article
- Below-the-knee Amputation with Targeted Muscle Reinnervation: Operative Technique and Technical Pearls.Plastic and reconstructive surgery. Global open · 2023Article
- Icing the Pain-Ultrasound-Guided Cryoablation of Symptomatic Post-Amputation Stump Neuroma.Cardiovascular and interventional radiology · 2022Observational
- Regenerative Peripheral Nerve Interfaces Effectively Prevent Neuroma Formation After Sciatic Nerve Transection in Rats.Frontiers in molecular neuroscience · 2022Article
- Surgical Approaches for Prevention of Neuroma at Time of Peripheral Nerve Injury.Frontiers in surgery · 2022Review
- Management of Phantom Limb Pain through Thalamotomy of the Centro-Median Nucleus.Neurology international · 2021Article
- Complex regional pain syndrome of the residual limb in a transtibial lower-limb amputee: diagnosis and treatment.BMJ case reports · 2021Article
- Psychiatric understanding and treatment of patients with amputations.Yeungnam University journal of medicine · 2021Article
- Sex-specific Differences in Multisite Pain Presentation among Adults with Lower-Limb Loss.Pain practice : the official journal of World Institute of Pain · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo define clinical phenotypes of postamputation pain and identify markers of risk for the development of chronic pain.
designCross-sectional study of military service members enrolled 3-18 months after traumatic amputation injury.
settingMilitary Medical Center. SUBJECTS: 124 recent active duty military service members.
methodsStudy subjects completed multiple pain and psychometric questionnaires to assess the qualities of phantom and residual limb pain. Medical records were reviewed to determine the presence/absence of a regional catheter near the time of injury. Subtypes of residual limb pain (somatic, neuroma, and complex regional pain syndrome) were additionally analyzed and associated with clinical risk factors.
resultsA majority of enrolled patients (64.5%) reported clinically significant pain (pain score ≥ 3 averaged over previous week). 61% experienced residual limb pain and 58% experienced phantom pain. When analysis of pain subtypes was performed in those with residual limb pain, we found evidence of a sensitized neuroma in 48.7%, somatic pain in 40.8%, and complex regional pain syndrome in 19.7% of individuals. The presence of clinically significant neuropathic residual limb pain was associated with symptoms of PTSD and depression. Neuropathic pain of any severity was associated with symptoms of all four assessed clinical risk factors: depression, PTSD, catastrophizing, and the absence of regional analgesia catheter.
conclusionsMost military service members in this cohort suffered both phantom and residual limb pain following amputation. Neuroma was a common cause of neuropathic pain in this group. Associated risk factors for significant neuropathic pain included PTSD and depression. PTSD, depression, catastrophizing, and the absence of a regional analgesia catheter were associated with neuropathic pain of any severity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.