ArticleTransplantation2016
Long-term Outcomes After Liver Transplantation Among Human Immunodeficiency Virus-Infected Recipients.
Article in Transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Current status of liver transplantation for human immunodeficiency virus-infected patients in mainland China.World journal of gastroenterology · 2024Article
- Liver Transplantation in People Living with HIV: Still an Experimental Procedure or Standard of Care?Life (Basel, Switzerland) · 2023Review
- Evaluation and management of post-transplant infections for the hepatologist.Clinical liver disease · 2023Review
- Pharmacotherapeutic Interventions in People Living With HIV Undergoing Solid Organ Transplantation: A Scoping Review.Transplantation direct · 2023Article
- HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
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- Liver Transplantation for HCC in HIV-Infected Patients: Long-Term Single-Center Experience.Cancers · 2021Article
- miRNA expression profiles in liver grafts of HCV and HIV/HCV-infected recipients, 6 months after liver transplantation.Journal of medical virology · 2021Article
- Science Over Stigma: Lessons and Future Direction of HIV-to-HIV Transplantation.Current transplantation reports · 2021Review
- Impact of the donor-recipient gender matching on the graft survival from live donors.BMC nephrology · 2020Article
- Comparison of Ceftizoxime Plus Ampicillin-Sulbactam versus Gentamicin Plus Ampicillin-Sulbactam in the Prevention of Post-Transplant Early Bacterial Infections in Liver Transplant Recipients: A Randomized Controlled Trial.Infection and drug resistance · 2020Article
- Successful optimization of antiretroviral regimens in treatment-experienced people living with HIV undergoing liver transplantation.Transplant infectious disease : an official journal of the Transplantation Society · 2019Article
- Solid Organ Transplantation in HIV-Infected Recipients: History, Progress, and Frontiers.Current HIV/AIDS reports · 2019Review
- Disseminated Intravascular Coagulation Following Heart Transplant in an HIV-infected Recipient: Case Report and Review of the Literature.Transplantation direct · 2019Article
- Knowledge, attitudes, and planned practice of HIV-positive to HIV-positive transplantation in US transplant centers.Clinical transplantation · 2018Article
- Moving from the HIV Organ Policy Equity Act to HIV Organ Policy Equity in action: changing practice and challenging stigma.Current opinion in organ transplantation · 2018Review
- Solid Organ Transplantation for HIV-Infected Individuals.Current treatment options in infectious diseases · 2018Article
- HIV+ deceased donor referrals: A national survey of organ procurement organizations.Clinical transplantation · 2018Article
- Successful direct acting antiviral (DAA) treatment of HCV/HIV-coinfected patients before and after liver transplantation.PloS one · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundEarly outcomes after human immunodeficiency virus (HIV) + liver transplantation (LT) are encouraging, but data are lacking regarding long-term outcomes and comparisons with matched HIV- patients.
methodsWe examined outcomes among 180 HIV+ LT, and compared outcomes to matched HIV- counterfactuals (Scientific Registry of Transplant Recipients 2002-2011). Iterative expanding radius matching (1:10) on recipient age, race, body mass index, hepatitis C virus (HCV), model for end-stage liver disease score, and acute rejection; and donor age and race, cold ischemia time, and year of transplant. Patient survival and graft survival were estimated using Kaplan-Meier methodology and compared using log-rank and Cox proportional hazards. Subgroup analyses were performed by transplant era (early: 2002-2007 vs. modern: 2008-2011) and HCV infection status.
resultsCompared to matched HIV- controls, HIV+ LT recipients had a 1.68-fold increased risk for death (adjusted hazard ratio [aHR], 1.68, 95% confidence interval [95% CI], 1.28-2.20; P < 0.001), and a 1.70-fold increased risk for graft loss (aHR, 1.70; 95% CI, 1.31-2.20; P < 0.001). These differences persisted independent of HCV infection status. However, in the modern transplant era risk for death (aHR, 1.11; 95% CI, 0.52-2.35; P = 0.79) and graft loss (aHR, 0.89; 95% CI, 0.42-1.88; P = 0.77) were similar between monoinfected and uninfected LT recipients. In contrast, independent of transplant era, coinfected LT recipients had increased risk for death (aHR, 2.24; 95% CI, 1.43-3.53; P < 0.001) and graft loss (aHR, 2.07; 95% CI, 1.33-3.22; P = 0.001) compared to HCV+ alone LT recipients.
conclusionsThese results suggest that outcomes among monoinfected HIV+ LT recipients have improved over time. However, outcomes among HIV+ LT recipients coinfected with HCV remain concerning and motivate future survival benefit studies.
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