ArticlePloS one2015
Insect Antimicrobial Peptide Complexes Prevent Resistance Development in Bacteria.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Article
- Resisting the resistance: the antimicrobial peptide DGL13K selects for small colony variants ofJournal of bacteriology · 2025Article
- Proline-Rich Antimicrobial Peptides from Invertebrates.Molecules (Basel, Switzerland) · 2024Review
- Article
- Effect of a Probiotic Beverage Enriched with Cricket Proteins on the Gut Microbiota: Composition of Gut and Correlation with Nutritional Parameters.Foods (Basel, Switzerland) · 2024Article
- Article
- Could Insect Products Provide a Safe and Sustainable Feed Alternative for the Poultry Industry? A Comprehensive Review.Animals : an open access journal from MDPI · 2023Review
- Bioactive Peptide Discovery from Edible Insects for Potential Applications in Human Health and Agriculture.Molecules (Basel, Switzerland) · 2023Review
- Available for millions of years but discovered through the last decade: Insects as a source of nutrients and energy in animal diets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- A Novel Proline-Rich Cathelicidin from the AlpacaMembranes · 2022Article
- Article
- Article
- The Silkworm as a Source of Natural Antimicrobial Preparations: Efficacy on Various Bacterial Strains.Antibiotics (Basel, Switzerland) · 2021Article
- Antimicrobial Peptides from Black Soldier Fly (Animals : an open access journal from MDPI · 2021Review
- Antifungals, arthropods and antifungal resistance prevention: lessons from ecological interactions.Proceedings. Biological sciences · 2021Article
- Threats to adhesive/dentin interfacial integrity and next generation bio-enabled multifunctional adhesives.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Review
- Sarconesin II, a New Antimicrobial Peptide Isolated fromMolecules (Basel, Switzerland) · 2019Article
- Proteomics and Lipidomics of Black Soldier Fly (Diptera: Stratiomyidae) and Blow Fly (Diptera: Calliphoridae) Larvae.Journal of insect science (Online) · 2019Article
- Peptide Mediated Antimicrobial Dental Adhesive System.Applied sciences (Basel, Switzerland) · 2019Article
- Insect Antimicrobial Peptides, a Mini Review.Toxins · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent decades much attention has been paid to antimicrobial peptides (AMPs) as natural antibiotics, which are presumably protected from resistance development in bacteria. However, experimental evolution studies have revealed prompt resistance increase in bacteria to any individual AMP tested. Here we demonstrate that naturally occurring compounds containing insect AMP complexes have clear advantage over individual peptide and small molecule antibiotics in respect of drug resistance development. As a model we have used the compounds isolated from bacteria challenged maggots of Calliphoridae flies. The compound isolated from blow fly Calliphora vicina was found to contain three distinct families of cell membrane disrupting/permeabilizing peptides (defensins, cecropins and diptericins), one family of proline rich peptides and several unknown antimicrobial substances. Resistance changes under long term selective pressure of the compound and reference antibiotics cefotaxime, meropenem and polymyxin B were tested using Escherichia coli, Klebsiella pneumonia and Acinetobacter baumannii clinical strains. All the strains readily developed resistance to the reference antibiotics, while no signs of resistance growth to the compound were registered. Similar results were obtained with the compounds isolated from 3 other fly species. The experiments revealed that natural compounds containing insect AMP complexes, in contrast to individual AMP and small molecule antibiotics, are well protected from resistance development in bacteria. Further progress in the research of natural AMP complexes may provide novel solutions to the drug resistance problem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.