ArticlePloS one2015
Association between Vitamin D and Circulating Lipids in Early Childhood.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Measurement of screen time among young children aged 0-6 years: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Effects of vitamin D supplementation on cardiometabolic outcomes in children and adolescents: a systematic review and meta-analysis of randomized controlled trials.European journal of nutrition · 2020Pooled it
- Vitamin D status and cardiometabolic risk markers in young Swedish children: a double-blind randomized clinical trial comparing different doses of vitamin D supplements.The American journal of clinical nutrition · 2020Trial
- Serum HDL-C levels in children with epilepsy: a single-center retrospective study.Frontiers in nutrition · 2025Article
- Review
- Vitamin D status of 3-year-old children in Denmark: determinants and associations with bone mineralisation and blood lipids.European journal of nutrition · 2023Article
- Vitamin D Supplementation in the Assessment of Cardiovascular Risk Factors in Overweight and Obese Children.Medical sciences (Basel, Switzerland) · 2022Observational
- Association of Vitamin D Status and Physical Activity with Lipid Profile in Korean Children and Adolescents: A Population-Based Study.Children (Basel, Switzerland) · 2020Article
- Article
- Treatment with Vitamin D3 in Vitamin D Deficient Adolescents: A Pilot Study.Global pediatric health · 2020Article
- Reduction of Some Atherogenic Indices in Patients with Non-Alcoholic Fatty Liver by Vitamin D and Calcium Co-Supplementation: A Double Blind Randomized Controlled Clinical Trial.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Relationship between 25 hydroxyvitamin D and lipid profile in Lebanese school children.Journal of endocrinological investigation · 2018Article
- Vitamin D Deficiency Associated With Markers of Cardiovascular Disease in Children With Obesity.Global pediatric health · 2018Article
- Vitamin D Deficiency and Association With Body Mass Index and Lipid Levels in Hispanic American Adolescents.Global pediatric health · 2017Article
- Vitamin D Supplementation and High-Density Lipoprotein Cholesterol: A Study in Healthy School Children.Iranian journal of pediatrics · 2016Article
- Associations between Serum 25-hydroxyvitamin D and Lipids, Lipoprotein Cholesterols, and Homocysteine.North American journal of medical sciences · 2016Article
- Vitamin D nutritional status and the risk for cardiovascular disease.Experimental and therapeutic medicine · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Vitamin D is associated with established cardiovascular risk factors such as low density lipoprotein (LDL) in adults. It is unknown whether these associations are present in early childhood. To determine whether serum 25-hydroxyvitamin D (25(OH)D) is associated with serum non-high density lipoprotein (non-HDL) cholesterol during early childhood we conducted a cross-sectional study of children aged 1 to 5 years. Healthy children were recruited through the TARGet Kids! practice based research network from 2008-2011 (n=1,961). The associations between 25(OH)D and non-fasting non-HDL cholesterol (the primary endpoint), total cholesterol, triglycerides, HDL, and low density lipoprotein (LDL) cholesterol, were evaluated using multiple linear regression adjusted for age, sex, skin pigmentation, milk intake, vitamin D supplementation, season, body mass index, outdoor play, and screen time. Each 10 nmol/L increase in 25(OH)D was associated with a decrease in non-HDL cholesterol concentration of -0.89 mg/dl (95% CI: -1.16,-0.50), total cholesterol of -1.08 mg/dl (95%CI: -1.49,-0.70), and triglycerides of -2.34 mg/dl (95%CI: -3.23,-1.45). The associations between 25(OH)D and LDL and HDL were not statistically significant. 25(OH)D concentrations were inversely associated with circulating lipids in early childhood, suggesting that vitamin D exposure in early life may be an early modifiable risk factor for cardiovascular disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.