ArticlePloS one2015
First Description of a New Disease in Rainbow Trout (Oncorhynchus mykiss (Walbaum)) Similar to Heart and Skeletal Muscle Inflammation (HSMI) and Detection of a Gene Sequence Related to Piscine Orthoreovirus (PRV).
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Proliferative Kidney Disease and Viral Pathogens in Wild Brown Trout (Salmo trutta) Populations in the Czech Republic.Journal of fish diseases · 2026Article
- Comparative Analysis of PRV-1 in Atlantic Salmon and PRV-3 in Coho Salmon: Host-Specific Immune Responses and Apoptosis in Red Blood Cells.Microorganisms · 2025Article
- Beating Cardiac Cell Cultures From Different Developmental Stages of Rainbow Trout as a Novel Approach for Replication of Cardiac Fish Viruses.Journal of fish diseases · 2025Article
- Pathogens from salmon aquaculture in relation to conservation of wild Pacific salmon in Canada.Science advances · 2024Review
- Current Challenges of Vaccination in Fish Health Management.Animals : an open access journal from MDPI · 2024Review
- A novel high-throughput qPCR chip for solving co-infections in RAS farmed rainbow trout.Scientific reports · 2024Article
- Detection, sequencing, and tissue distribution of piscine orthoreovirus 2-like virus in diseased coho salmon in Alaska.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Analyses and Insights into Genetic Reassortment and Natural Selection as Key Drivers ofViruses · 2024Article
- Five Species of Wild Freshwater Sport Fish in Wisconsin, USA, Reveal Highly Diverse Viromes.Pathogens (Basel, Switzerland) · 2024Article
- Assessing the role of Piscine orthoreovirus in disease and the associated risk for wild Pacific salmon.BMC biology · 2023Article
- Discovery of an unrecognized nidovirus associated with granulomatous hepatitis in rainbow trout.iScience · 2023Article
- Decreased water temperature enhanceFrontiers in veterinary science · 2023Article
- Nuclear DNA Content Variation in Different Life Cycle Stages of Sugar Kelp, Saccharina latissima.Marine biotechnology (New York, N.Y.) · 2022Article
- Pan-Piscine Orthoreovirus (PRV) Detection Using Reverse Transcription Quantitative PCR.Pathogens (Basel, Switzerland) · 2021Article
- Aquaculture mediates global transmission of a viral pathogen to wild salmon.Science advances · 2021Article
- Article
- Extensive Phylogenetic Analysis of Piscine Orthoreovirus Genomic Sequences Shows the Robustness of Subgenotype Classification.Pathogens (Basel, Switzerland) · 2021Article
- Emergence and Spread ofPathogens (Basel, Switzerland) · 2020Article
- Revision of Coelastrella (Scenedesmaceae, Chlorophyta) and first register of this green coccoid microalga for continental Norway.World journal of microbiology & biotechnology · 2020Article
- Health Surveillance of Wild Brown Trout (Pathogens (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In fall 2013, anorexia, lethargy and mortalities up to 10-12,000 dead fish per week were observed in rainbow trout Oncorhynchus mykiss in three fresh water hatcheries (salinity 0-1 ‰) on the west coast of Norway. The fish (25-100 g) showed signs of circulatory failure with haemorrhages, ascites and anaemia. The histopathological findings comprised inflammation of the heart and red muscle and liver necrosis. The affected fish had a common origin. Disease and mortalities were also observed up to four months after sea water transfer. Microbiological examination did not reveal presence of any known pathogens. Based on histopathological similarities to heart and skeletal inflammation (HSMI) in Atlantic salmon, associated with piscine orthoreovirus (PRV), extended investigations to detect a virus within the family Reoviridae were conducted. By the use of primer sets targeting the PRV genome, a sequence with 85% identity to a part of segment S1 of PRV was obtained. Further analysis showed that the virus sequence could only be aligned with PRV and no other reoviruses both on amino acid and nucleotide level. Two PCR assays were developed for specific detection of the virus. High amounts of the virus were detected in diseased fish at all affected farms and low amounts were detected in low prevalence at the broodfish farms. Further investigations are needed to determine if the virus is associated with the new disease in rainbow trout and to further characterize the virus with respect to classification, relationship with PRV, virulence, pathology and epidemiology.
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