Evidence map›Paper›PMID 26176943›Full record

Observational studyPloS one2015

An Artificial Neural Network Stratifies the Risks of Reintervention and Mortality after Endovascular Aneurysm Repair; a Retrospective Observational study.

Alan Karthikesalingam, Omneya Attallah, Xianghong Ma, Sandeep Singh Bahia, Luke Thompson, Alberto Vidal-Diez, Edward C Choke, Matt J Bown, Robert D Sayers, Matt M Thompson and 1 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 71 citations in OpenAlex.

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  10. Machine learning model predicts the occurrence of acute kidney injury after open surgery for abdominal aortic aneurysm repair.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  11. RADIC:A tool for diagnosing COVID-19 from chest CT and X-ray scans using deep learning and quad-radiomics.Chemometrics and intelligent laboratory systems : an international journal sponsored by the Chemometrics Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Alan KarthikesalingamDepartment of Outcomes Research, St George's Vascular Institute, London, SW17 0QT, United Kingdom.
Omneya AttallahCollege of Engineering and Applied Science, Aston University, Birmingham, B4 7ET, United Kingdom; Department of Electronics and Communications Engineering, Arab Academy for Science and Technology and Maritime Transport, Alexandria, Egypt.
Xianghong MaCollege of Engineering and Applied Science, Aston University, Birmingham, B4 7ET, United Kingdom.
Sandeep Singh BahiaDepartment of Outcomes Research, St George's Vascular Institute, London, SW17 0QT, United Kingdom.
Luke ThompsonDepartment of Outcomes Research, St George's Vascular Institute, London, SW17 0QT, United Kingdom.
Alberto Vidal-DiezDepartment of Outcomes Research, St George's Vascular Institute, London, SW17 0QT, United Kingdom; Department of Community Health Sciences, St George's University of London, London, SW17 0QT, United Kingdom.
Edward C ChokeVascular Surgery Group, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, United Kingdom.
Matt J BownVascular Surgery Group, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, United Kingdom.
Robert D SayersVascular Surgery Group, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, United Kingdom.
Matt M ThompsonDepartment of Outcomes Research, St George's Vascular Institute, London, SW17 0QT, United Kingdom.
Peter J HoltDepartment of Outcomes Research, St George's Vascular Institute, London, SW17 0QT, United Kingdom.
University of Leicester · GBAston University · GBSt George's, University of London · GB

Funding

Department of Health NIHR-CS-011-008
6 · The paper itself

Abstract

backgroundLifelong surveillance after endovascular repair (EVAR) of abdominal aortic aneurysms (AAA) is considered mandatory to detect potentially life-threatening endograft complications. A minority of patients require reintervention but cannot be predictively identified by existing methods. This study aimed to improve the prediction of endograft complications and mortality, through the application of machine-learning techniques.

methodsPatients undergoing EVAR at 2 centres were studied from 2004-2010. Pre-operative aneurysm morphology was quantified and endograft complications were recorded up to 5 years following surgery. An artificial neural networks (ANN) approach was used to predict whether patients would be at low- or high-risk of endograft complications (aortic/limb) or mortality. Centre 1 data were used for training and centre 2 data for validation. ANN performance was assessed by Kaplan-Meier analysis to compare the incidence of aortic complications, limb complications, and mortality; in patients predicted to be low-risk, versus those predicted to be high-risk.

results761 patients aged 75 +/- 7 years underwent EVAR. Mean follow-up was 36+/- 20 months. An ANN was created from morphological features including angulation/length/areas/diameters/volume/tortuosity of the aneurysm neck/sac/iliac segments. ANN models predicted endograft complications and mortality with excellent discrimination between a low-risk and high-risk group. In external validation, the 5-year rates of freedom from aortic complications, limb complications and mortality were 95.9% vs 67.9%; 99.3% vs 92.0%; and 87.9% vs 79.3% respectively (p<0.001).

conclusionThis study presents ANN models that stratify the 5-year risk of endograft complications or mortality using routinely available pre-operative data.

Indexed as

Neural Networks, ComputerAgedAged, 80 and overAortic Aneurysm, AbdominalEndovascular ProceduresFemaleHumansMalePostoperative ComplicationsRetreatmentRetrospective StudiesRisk Assessment

Identifiers

PMID26176943
PMCPMC4503678
OpenAlexW2227128625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.