ArticleJournal of cellular and molecular medicine2015
The secretome of myocardial telocytes modulates the activity of cardiac stem cells.
Article in Journal of cellular and molecular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 110 citations in OpenAlex.
- Telocytes in skeletal muscle: Emerging players in homeostasis and repair/regeneration.Histology and histopathology · 2026Review
- Telocytes Twenty Years on: A Critical Reappraisal of Identity, Function, and Pathological Relevance.International journal of molecular sciences · 2026Review
- Exercise intensity-dependent cardiac telocyte expansion is associated with physiological growth despite JAK/STAT pathway inactivity in male Wistar rats.Experimental physiology · 2026Article
- Telocytes: history, origin, identification, structure, distribution, and functions.Histochemistry and cell biology · 2025Review
- Transcriptomic and Histological Characterization of Telocytes in the Human Dorsal Root Ganglion.The Journal of comparative neurology · 2025Article
- Skin Telocyte Secretome as Conditioned Medium Prevents Profibrotic Differentiation of Skin Fibroblasts into Myofibroblasts.International journal of molecular sciences · 2025Article
- Transcriptomic and histological characterization of telocytes in the human dorsal root ganglion.bioRxiv : the preprint server for biology · 2024Article
- Dynamic relationship among extracellular matrix and body wall cells in Hirudo verbana morphogenesis.Cell and tissue research · 2024Article
- Telocytes: current methods of research, challenges and future perspectives.Cell and tissue research · 2024Review
- A transmission electron microscopy investigation suggests that telocytes, skeletal muscles, myoblasts, and stem cells in common carp (Cyprinus carpio) respond to salinity challenges.BMC veterinary research · 2024Article
- Vascular endothelial growth factor facilitates the effects of telocytes on tumor cell proliferation and migration.Frontiers in cell and developmental biology · 2024Article
- A cellular regulator of the niche: telocyte.Tissue barriers · 2023Review
- Identification and protective role of CD34Histochemistry and cell biology · 2023Article
- Telocytes response to cardiac growth induced by resistance exercise training and endurance exercise training in adult male rats.The journal of physiological sciences : JPS · 2023Article
- Molecular Mechanisms and Key Processes in Interstitial, Hemorrhagic and Radiation Cystitis.Biology · 2022Review
- Telocytes' Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review.International journal of molecular sciences · 2022Review
- Telocytes reduce oxidative stress by downregulating DUOX2 expression in inflamed lungs of mice.Acta biochimica et biophysica Sinica · 2022Article
- Cardiac stem cells: Current knowledge and future prospects.World journal of stem cells · 2022Review
- Adult stem cell niches for tissue homeostasis.Journal of cellular physiology · 2022Review
- Telocytes and Their Structural Relationships With the Sperm Storage Tube and Surrounding Cell Types in the Utero-Vaginal Junction of the Chicken.Frontiers in veterinary science · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telocytes (TCs) are interstitial cells that are present in numerous organs, including the heart interstitial space and cardiac stem cell niche. TCs are completely different from fibroblasts. TCs release extracellular vesicles that may interact with cardiac stem cells (CSCs) via paracrine effects. Data on the secretory profile of TCs and the bidirectional shuttle vesicular signalling mechanism between TCs and CSCs are scarce. We aimed to characterize and understand the in vitro effect of the TC secretome on CSC fate. Therefore, we studied the protein secretory profile using supernatants from mouse cultured cardiac TCs. We also performed a comparative secretome analysis using supernatants from rat cultured cardiac TCs, a pure CSC line and TCs-CSCs in co-culture using (i) high-sensitivity on-chip electrophoresis, (ii) surface-enhanced laser desorption/ionization time-of-flight mass spectrometry and (iii) multiplex analysis by Luminex-xMAP. We identified several highly expressed molecules in the mouse cardiac TC secretory profile: interleukin (IL)-6, VEGF, macrophage inflammatory protein 1α (MIP-1α), MIP-2 and MCP-1, which are also present in the proteome of rat cardiac TCs. In addition, rat cardiac TCs secrete a slightly greater number of cytokines, IL-2, IL-10, IL-13 and some chemokines like, GRO-KC. We found that VEGF, IL-6 and some chemokines (all stimulated by IL-6 signalling) are secreted by cardiac TCs and overexpressed in co-cultures with CSCs. The expression levels of MIP-2 and MIP-1α increased twofold and fourfold, respectively, when TCs were co-cultured with CSCs, while the expression of IL-2 did not significantly differ between TCs and CSCs in mono culture and significantly decreased (twofold) in the co-culture system. These data suggest that the TC secretome plays a modulatory role in stem cell proliferation and differentiation.
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