ArticlePloS one2015
Up in Arms: Immune and Nervous System Response to Sea Star Wasting Disease.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- A Comparison of Juvenile and Adult Sunflower Sea Star Transcriptomic Responses to Challenge With Sea Star Wasting Disease Tissue Homogenates.Ecology and evolution · 2026Article
- A reference genome for ecological restoration of the sunflower sea star, Pycnopodia helianthoides.The Journal of heredity · 2024Article
- Sea stars resist wasting through active immune and collagen systems.Proceedings. Biological sciences · 2023Article
- Two decades of change in sea star abundance at a subtidal site in Puget Sound, Washington.PloS one · 2023Article
- A chromosome-level reference genome for the giant pink sea star, Pisaster brevispinus, a species severely impacted by wasting.The Journal of heredity · 2022Article
- A Review of Asteroid Biology in the Context of Sea Star Wasting: Possible Causes and Consequences.The Biological bulletin · 2022Review
- The first records of sea star wasting disease inBiology letters · 2022Article
- Transcriptomic analysis of sea cucumber (Holothuria leucospilota) coelomocytes revealed the echinoderm cytokine response during immune challenge.BMC genomics · 2020Article
- Disease epidemic and a marine heat wave are associated with the continental-scale collapse of a pivotal predator (Science advances · 2019Article
- Sea star wasting disease demography and etiology in the brooding sea star Leptasterias spp.PloS one · 2019Article
- Exploring the pathology of an epidermal disease affecting a circum-Antarctic sea star.Scientific reports · 2018Article
- Decimation by sea star wasting disease and rapid genetic change in a keystone species,Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Transcriptional analyses provide new insight into the late-stage immune response of a diseased Caribbean coral.Royal Society open science · 2018Article
- From compliment to insult: genetics of the complement system in physiology and disease in the human retina.Human molecular genetics · 2017Review
- RNA sequencing analysis to capture the transcriptome landscape during skin ulceration syndrome progression in sea cucumber Apostichopus japonicus.BMC genomics · 2016Article
- Ochre star mortality during the 2014 wasting disease epizootic: role of population size structure and temperature.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
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Authors and funding
14 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Echinoderms, positioned taxonomically at the base of deuterostomes, provide an important system for the study of the evolution of the immune system. However, there is little known about the cellular components and genes associated with echinoderm immunity. The 2013-2014 sea star wasting disease outbreak is an emergent, rapidly spreading disease, which has led to large population declines of asteroids in the North American Pacific. While evidence suggests that the signs of this disease, twisting arms and lesions, may be attributed to a viral infection, the host response to infection is still poorly understood. In order to examine transcriptional responses of the sea star Pycnopodia helianthoides to sea star wasting disease, we injected a viral sized fraction (0.2 μm) homogenate prepared from symptomatic P. helianthoides into apparently healthy stars. Nine days following injection, when all stars were displaying signs of the disease, specimens were sacrificed and coelomocytes were extracted for RNA-seq analyses. A number of immune genes, including those involved in Toll signaling pathways, complement cascade, melanization response, and arachidonic acid metabolism, were differentially expressed. Furthermore, genes involved in nervous system processes and tissue remodeling were also differentially expressed, pointing to transcriptional changes underlying the signs of sea star wasting disease. The genomic resources presented here not only increase understanding of host response to sea star wasting disease, but also provide greater insight into the mechanisms underlying immune function in echinoderms.
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