ReviewKidney international2015
Kt/V (and especially its modifications) remains a useful measure of hemodialysis dose.
Review in Kidney international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
- Effect of transcutaneous vagus nerve stimulation in hemodialysis patients: A randomized controlled trial.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026Trial
- Trial
- Contribution of 'clinically negligible' residual kidney function to clearance of uremic solutes.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Trial
- Cingulate Gradient Dysfunction in End-Stage Renal Disease: Associations With Clinical Phenotypes and Exploratory Transcriptomic Signatures.CNS neuroscience & therapeutics · 2026Article
- The Associations Between Dialysis Treatment Time, Mortality, and Hospitalizations in a Large Hemodialysis Cohort.Kidney international reports · 2026Article
- Development and Preliminary Testing of the Healthy Transition Scale for Patients Undergoing Haemodialysis.International journal of nursing practice · 2026Article
- Low fT3 Syndrome, Dialysis Inadequacy, and Death Occurrence in Hemodialysis Patients: Evidence of a Vicious Circle from a Prospective Bi-Center Observational Study.Journal of clinical medicine · 2026Article
- Dialysis adequacy revisited: Kt/V's blind spot for phosphorus and iodine.Journal of translational internal medicine · 2025Article
- Brain connectome gradient dysfunction in patients with end-stage renal disease and its association with clinical phenotype and cognitive deficits.Communications biology · 2025Article
- Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study.Renal failure · 2024Article
- The impact of dialysate flow rate on haemodialysis adequacy: a systematic review and meta-analysis.Clinical kidney journal · 2024Article
- Dependency and frailty in the older haemodialysis patient.BMC geriatrics · 2024Observational
- Incidence and Predictors of Acute Coronary Syndrome in Patients on Maintenance Hemodialysis: A Prospective Cohort Study.Acta Cardiologica Sinica · 2024Article
- A Sarcopenia Index Derived from Malnutrition Parameters in Elderly Haemodialysis Patients.Nutrients · 2023Article
- Relationship between symptom burden and dialysis adequacy in patients with chronic kidney disease undergoing hemodialysis.Northern clinics of Istanbul · 2023Article
- Chronic hemodialysis: Evaluation of dialysis adequacy and mortality.Annals of medicine and surgery (2012) · 2022Article
- Twice-weekly hemodialysis in the time of COVID-19: a multicenter study in prevalent patients.Clinical kidney journal · 2021Article
- Serum Hepcidin-25 and All-Cause Mortality in Patients Undergoing Maintenance Hemodialysis.International journal of general medicine · 2021Article
- Citrate anion improves chronic dialysis efficacy, reduces systemic inflammation and prevents Chemerin-mediated microvascular injury.Scientific reports · 2019Article
- Middle molecule elimination in expanded haemodialysis: only convective transport?Clinical kidney journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Removal of small molecular weight solutes shows a strong relationship to hemodialysis outcomes. In contrast, survival with high-flux dialysis or hemodiafiltration is only slightly better than with low-flux hemodialysis. Despite laboratory evidence regarding toxicity of protein-bound uremic solutes, few data exist showing that increased removal of this class of molecules impacts outcomes. In the FHN trials, there was no effect of frequent dialysis, including frequent and long dialysis, on nutrition or control of anemia, outcomes expected to be sensitive to uremic toxin removal; the main benefit appeared to be better volume control. Scaling of hemodialysis dose to total body water may not be optimal. Kt/V scaling to body surface area and use of a continuous measure such as standard Kt/V reduces the likelihood of underdialysis of small patients, including children, and women. Minimum hemodialysis time may best be considered in respect to ultrafiltration rate, and a maximum target ultrafiltration rate unscaled to body size may be optimal. Intensive, extended dialysis may cause adverse effects to residual kidney function, and more information needs to be collected to better understand how urine volume modifies dose requirements, and how to maximize the chances of preserving residual kidney function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.