Evidence map›Paper›PMID 26176759›Full record

ArticleThe Journal of investigative dermatology2015

Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1.

Shreya Bhattacharya, Heather Wheeler, Mark Leid, Gitali Ganguli-Indra, Arup K Indra

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System.Frontiers in cell and developmental biology · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shreya BhattacharyaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA; Molecular Cell Biology Program, Oregon State University, Corvallis, Oregon, USA.
Heather WheelerDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon, USA.
Mark LeidDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA; Molecular Cell Biology Program, Oregon State University, Corvallis, Oregon, USA; Department of Integrative Biosciences, Oregon Health & Science University, Portland, Oregon, USA.
Gitali Ganguli-IndraDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA; Molecular Cell Biology Program, Oregon State University, Corvallis, Oregon, USA. Electronic address: arup.indra@oregonstate.edu.
Arup K IndraDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA; Molecular Cell Biology Program, Oregon State University, Corvallis, Oregon, USA; Environmental Health Science Center, Oregon State University, Corvallis, Oregon, USA; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA; Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA. Electronic address: arup.indra@oregonstate.edu.
Oregon State University · USOregon Health & Science University · US

Funding

Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation, R01AR056008 · NIAMS · OREGON STATE UNIVERSITY · PI INDRA, ARUP K. · 2008 to 2012
$1.5M
NIAMS NIH HHS AR056008NIAMS NIH HHS R01 AR056008
6 · The paper itself

Abstract

Transcription factor CTIP2 (chicken ovalbumin upstream promoter transcription factor-interacting protein 2), also known as BCL11B, is expressed in hair follicles (HFs) of embryonic and adult skin. Ctip2-null mice exhibit reduced HF density during embryonic development. In contrast, conditional inactivation of Ctip2 in the epidermis (Ctip2(ep-/-) mice) leads to a shorter telogen and a premature entry into anagen during the second phase of hair cycling without a detectable change in the number of HFs. Keratinocytes of the bulge stem cells (SCs) niche of Ctip2(ep-/-) mice proliferate more and undergo reduced apoptosis compared with the corresponding cells of wild-type mice. However, premature activation of follicular SCs in mice lacking CTIP2 leads to the exhaustion of this SC compartment in comparison with Ctip2(L2/L2) mice, which retained quiescent follicle SCs. CTIP2 modulates expression of genes encoding EGFR and NOTCH1 during formation of HFs and those encoding nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 and LIM homeobox 2 during normal hair cycling in adult skin. The expression of most of these genes is disrupted in mice lacking CTIP2, and these alterations may underlie the phenotype of Ctip2-null and Ctip2(ep-/-) mice. CTIP2 appears to serve as a transcriptional organizer that integrates input from multiple signaling cues during HF morphogenesis and hair cycling.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsCell DifferentiationCells, CulturedFemaleHairHair FollicleKeratinocytesLIM-Homeodomain ProteinsMiceMice, KnockoutModels, AnimalNFATC Transcription FactorsRepressor ProteinsSensitivity and SpecificitySignal TransductionBCL11B protein, humanLhx2 protein, mouseLIM-Homeodomain ProteinsNfatc1 protein, mouseNFATC Transcription FactorsRepressor ProteinsTranscription FactorsTumor Suppressor Proteins

Identifiers

PMID26176759
PMCPMC4640969
OpenAlexW906738742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.