Evidence map›Paper›PMID 26176690›Full record

ArticleChannels (Austin, Tex.)2016

A rendezvous with the queen of ion channels: Three decades of ion channel research by David T Yue and his Calcium Signals Laboratory.

Ivy E Dick, Worawan B Limpitikul, Jacqueline Niu, Rahul Banerjee, John B Issa, Manu Ben-Johny, Paul J Adams, Po Wei Kang, Shin Rong Lee, Lingjie Sang and 6 more

Abstract readAutobiographyBiographyHistorical Article
PubMed Full text at PMC Publisher
In one paragraph

Article in Channels (Austin, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Calmodulin modulates the CaIBRO reports · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ivy E Dicka Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Worawan B Limpitikula Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Jacqueline Niua Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Rahul Banerjeea Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
John B Issaa Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Manu Ben-Johnya Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Paul J Adamsa Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Po Wei Kanga Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Shin Rong Leea Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Lingjie Sanga Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Wanjun Yanga Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Jennifer Babicha Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Manning Zhanga Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Hojjat Bazazzia Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Nancy C Yuea Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Gordon F Tomasellia Calcium Signals Laboratory; Department of Biomedical Engineering ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
Ca Regulation of Ca ChannelsR01MH065531 · NIMH · JOHNS HOPKINS UNIVERSITY · PI JOHNY, MANU BEN · 2002 to 2016
$5.7M
Structural Basis of the Regulation of Na ChannelsR01HL050411 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TOMASELLI, GORDON FRANK · 1994 to 2013
$4.4M
Calmodulin/Ca Channel Physiology in HeartR37HL076795 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI YUE, DAVID T · 2004 to 2013
$4.1M
Dynamic Calmodulin Regulation of Na ChannelsR01NS073874 · NINDS · JOHNS HOPKINS UNIVERSITY · PI TOMASELLI, GORDON FRANK · 2011 to 2015
$1.9M
Chemical biological dissection of Ca2+ entry through Ca2+ channelsR01NS085074 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI DICK, IVY E · 2013 to 2016
$1.3M
NHLBI NIH HHS HL50411NHLBI NIH HHS R37HL076795NIGMS NIH HHS T32 GM007309NIMH NIH HHS R01 MH065531NIMH NIH HHS R01MH065531NINDS NIH HHS R01 NS073874NINDS NIH HHS R01NS073874NINDS NIH HHS R01NS08074NINDS NIH HHS R01 NS085074
6 · The paper itself

Abstract

David T. Yue was a renowned biophysicist who dedicated his life to the study of Ca(2+) signaling in cells. In the wake of his passing, we are left not only with a feeling of great loss, but with a tremendous and impactful body of work contributed by a remarkable man. David's research spanned the spectrum from atomic structure to organ systems, with a quantitative rigor aimed at understanding the fundamental mechanisms underlying biological function. Along the way he developed new tools and approaches, enabling not only his own research but that of his contemporaries and those who will come after him. While we cannot hope to replicate the eloquence and style we are accustomed to in David's writing, we nonetheless undertake a review of David's chosen field of study with a focus on many of his contributions to the calcium channel field.

Indexed as

Calcium SignalingAnimalsBiophysicsCalcium ChannelsHistory, 20th CenturyHistory, 21st CenturyUnited StatesCalcium Channelsbiophysicscalcium channelcalmodulinprotein kinase Asingle channelssodium channel

Identifiers

PMID26176690
PMCPMC4802785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.