ArticlePloS one2015
Gene Transcriptional and Metabolic Profile Changes in Mimetic Aging Mice Induced by D-Galactose.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Differential metabolic profiles by Hispanic ethnicity among male Tucson firefighters.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Gut microbiota and metabolic profile changes unveil the deterioration of alveolar bone inflammatory resorption with aging induced by D-galactose.Scientific reports · 2024Article
- Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway.Molecules (Basel, Switzerland) · 2024Article
- Gemigliptin Improves Salivary Gland Dysfunction in D-Galactose-Injected Aging Rats.Pharmaceutics · 2023Article
- Maternal obesity alters offspring liver and skeletal muscle metabolism in early post-puberty despite maintaining a normal post-weaning dietary lifestyle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Gut microbiome and metabolome analyses reveal the protective effect of special high-docosahexaenoic acid tuna oil on d-galactose-induced aging in mice.Food science & nutrition · 2022Article
- Ultrasonic treatment ofFood science & nutrition · 2022Article
- Integrated metabolomics and transcriptomics reveal the anti-aging effect of melanin fromAging · 2021Article
- Curcumin protects thymus against D-galactose-induced senescence in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Age-Related Metabolic Pathways Changes in Dental Follicles: A Pilot Study.Frontiers in oral health · 2021Article
- The antidiabetic and hepatoprotective effects of myricitrin on aged mice with D-galactose.Gastroenterology and hepatology from bed to bench · 2020Article
- Effects of apoptosis on liver aging.World journal of clinical cases · 2019Review
- Matrine Attenuates D-Galactose-Induced Aging-Related Behavior in MiceOxidative medicine and cellular longevity · 2018Article
- Tetrahydroxystilbene Glucoside (TSG) Restores the Effect of Transient Hypoxia on Reperfusion Injury in Senescent H9c2 Cells by Regulating Mitochondrial Energy Metabolism.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Pancreatic protective and hypoglycemic effects ofResearch in pharmaceutical sciences · 2017Article
- Article
- Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts byEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Acute kidney injury and inflammatory response of sepsis following cecal ligation and puncture in d-galactose-induced aging rats.Clinical interventions in aging · 2017Article
- Moderate exercise prevents neurodegeneration in D-galactose-induced aging mice.Neural regeneration research · 2016Article
- Anti-Apoptotic and Pro-Survival Effect of Alpinate Oxyphyllae Fructus (AOF) in a d-Galactose-Induced Aging Heart.International journal of molecular sciences · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
D-galactose injection has been shown to induce many changes in mice that represent accelerated aging. This mouse model has been widely used for pharmacological studies of anti-aging agents. The underlying mechanism of D-galactose induced aging remains unclear, however, it appears to relate to glucose and 1ipid metabolic disorders. Currently, there has yet to be a study that focuses on investigating gene expression changes in D-galactose aging mice. In this study, integrated analysis of gas chromatography/mass spectrometry-based metabonomics and gene expression profiles was used to investigate the changes in transcriptional and metabolic profiles in mimetic aging mice injected with D-galactose. Our findings demonstrated that 48 mRNAs were differentially expressed between control and D-galactose mice, and 51 potential biomarkers were identified at the metabolic level. The effects of D-galactose on aging could be attributed to glucose and 1ipid metabolic disorders, oxidative damage, accumulation of advanced glycation end products (AGEs), reduction in abnormal substance elimination, cell apoptosis, and insulin resistance.
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