Evidence map›Paper›PMID 26176493›Full record

ArticleHuman vaccines & immunotherapeutics2015

Do vitamin D levels affect antibody titers produced in response to HPV vaccine?

Richard K Zimmerman, Chyongchiou Jeng Lin, Jonathan M Raviotta, Mary Patricia Nowalk

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Richard K Zimmermana Department of Family Medicine ; University of Pittsburgh School of Medicine ; Pittsburgh PA USA.
Chyongchiou Jeng Lina Department of Family Medicine ; University of Pittsburgh School of Medicine ; Pittsburgh PA USA.
Jonathan M Raviottaa Department of Family Medicine ; University of Pittsburgh School of Medicine ; Pittsburgh PA USA.
Mary Patricia Nowalka Department of Family Medicine ; University of Pittsburgh School of Medicine ; Pittsburgh PA USA.
University of Pittsburgh · US

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
NCATS NIH HHS UL1TR000005NCRR NIH HHS UL1 RR024153
6 · The paper itself

Abstract

In addition to its well-known effects on bone metabolism, vitamin D is an immunomodulating hormone. Serum vitamin D levels in males 18-25 years were measured at baseline, and HPV antibody titers were measured one month following the third quadrivalent HPV vaccine dose. Vitamin D levels were ≥ 30 ng/ml (normal) in 60 males and <30 ng/ml (low) in 113 males. Reverse cumulative distribution curves and scatter plots showed higher antibody titers with low vitamin D for all vaccine strains (P < 0.05). In linear regression analyses, antibody titers for all HPV strains were significantly higher among those with lower vitamin D levels and among younger participants (P < 0.05). These relationships add to the body of knowledge of the complex role of vitamin D in immunoregulation.

Indexed as

AdolescentAdultAntibodies, ViralHumansImmunologic FactorsMalePapillomavirus VaccinesVitamin DYoung AdultAntibodies, ViralImmunologic FactorsPapillomavirus VaccinesVitamin DHPV vaccinehuman papillomavirusimmunogenicityimmunoregulationvitamin D

Identifiers

PMID26176493
PMCPMC4635898
OpenAlexW1938157508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.