ArticleOptics letters2015
Snap-shot multispectral imaging of vascular dynamics in a mouse window-chamber model.
Article in Optics letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- In vitro vascularization improves in vivo functionality of human engineered cardiac tissues.Acta biomaterialia · 2026Article
- Portable multi-parametric microscopy for noninvasive metabolic and vascular imaging of orthotopic tongue cancer modelsJournal of biomedical optics · 2025Article
- Point-of-care optical spectroscopy platform and ratio-metric algorithms for rapid and systematic functional characterization of biological modelsJournal of biomedical optics · 2024Article
- Hyperspectral imaging of 4T1 mammary carcinomas grown in dorsal skinfold window chambers: spectral renormalization and fluorescence modeling.Journal of biomedical optics · 2024Article
- Diffuse reflectance spectroscopy for optical characterizations of orthotopic head and neck cancer modelsBiomedical optics express · 2024Article
- Hyperspectral wide-field-of-view imaging to study dynamic microcirculatory changes during hypoxia.American journal of physiology. Heart and circulatory physiology · 2022Article
- Numerical investigation of depth-sensitive diffuse reflectance and fluorescence measurements on murine subcutaneous tissue with growing solid tumors.Biomedical optics express · 2020Article
- Evaluating online filtering algorithms to enhance dynamic multispectral optoacoustic tomography.Photoacoustics · 2020Article
- Converting a Common Low-Cost Document Scanner into a Multispectral Scanner.Sensors (Basel, Switzerland) · 2019Article
- Increased Hemoglobin Oxygen Affinity With 5-Hydroxymethylfurfural Supports Cardiac Function During Severe Hypoxia.Frontiers in physiology · 2019Article
- Two-wavelength oximetry of tissue microcirculation based on sidestream dark-field imaging.Journal of biomedical optics · 2018Article
- Effects of isoflurane anesthesia on physiological parameters in murine subcutaneous tumor allografts measured via diffuse reflectance spectroscopy.Biomedical optics express · 2018Article
- Optimization of wavelength selection for multispectral image acquisition: a case study of atrial ablation lesions.Biomedical optics express · 2018Article
- Autofluorescence hyperspectral imaging of radiofrequency ablation lesions in porcine cardiac tissue.Journal of biophotonics · 2017Article
- Multispectral oximetry of murine tendon microvasculature with inflammation.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Understanding tumor vascular dynamics through parameters such as blood flow and oxygenation can yield insight into tumor biology and therapeutic response. Hyperspectral microscopy enables optical detection of hemoglobin saturation or blood velocity by either acquiring multiple images that are spectrally distinct or by rapid acquisition at a single wavelength over time. However, the serial acquisition of spectral images over time prevents the ability to monitor rapid changes in vascular dynamics and cannot monitor concurrent changes in oxygenation and flow rate. Here, we introduce snap shot-multispectral imaging (SS-MSI) for use in imaging the microvasculature in mouse dorsal-window chambers. By spatially multiplexing spectral information into a single-image capture, simultaneous acquisition of dynamic hemoglobin saturation and blood flow over time is achieved down to the capillary level and provides an improved optical tool for monitoring rapid in vivo vascular dynamics.
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