ArticleCartilage2015
Pre-Osteoarthritis: Definition and Diagnosis of an Elusive Clinical Entity.
Article in Cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Surgery for early structural osteoarthritis of the hip and knee: the SCORE evidence synthesis and economic evaluation.Health technology assessment (Winchester, England) · 2026Pooled it
- Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Pooled it
- Pooled it
- Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis.Frontiers in physiology · 2021Pooled it
- Laboratory-selected, probioticFrontiers in nutrition · 2026Trial
- Ozone Therapy versus Hyaluronic Acid Injections for Pain Relief in Patients with Knee Osteoarthritis: Preliminary Findings on Molecular and Clinical Outcomes from a Randomized Controlled Trial.International journal of molecular sciences · 2023Trial
- Trial
- Assessment of degenerative states of articular cartilage via sparse laser-based mid-infrared attenuated total reflectance spectroscopy.Osteoarthritis and cartilage open · 2026Article
- Influence of Concomitant Articular Cartilage Injury on the Diagnostic Performance of Physical Examination Tests for Meniscal Tears.Orthopaedic journal of sports medicine · 2026Article
- Current State of Orthobiologics in Treatment of Knee Osteoarthritis-Future Directions.International journal of molecular sciences · 2026Review
- Investigating Sex-Linked miRNAs for Potential Osteoarthritis Therapy Biomarkers.International journal of molecular sciences · 2026Article
- A Multidimensional Definition of Pre-Osteoarthritis: Toward 21st-Century Subclinical Detection and Targeted Intervention.International journal of molecular sciences · 2025Review
- Increased synovitis and pro-inflammatory macrophage abundance are observed in the synovia of patients at risk of developing post-traumatic OA compared to those with established OA.Osteoarthritis and cartilage open · 2025Article
- Transformative approaches for effective clinical trials to reduce the disease burden of osteoarthritis.Seminars in arthritis and rheumatism · 2025Review
- Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management.Asian journal of pharmaceutical sciences · 2025Review
- Article
- Article
- Holistic vibrational spectromics assessment of human cartilage for osteoarthritis diagnosis.Biomedical optics express · 2024Article
- Laser-irradiating infrared attenuated total reflection spectroscopy of articular cartilage: Potential and challenges for diagnosing osteoarthritis.Osteoarthritis and cartilage open · 2024Article
- Histological and immunohistochemical analyses of articular cartilage during onset and progression of pre- and early-stage osteoarthritis in a rodent model.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 9 institutions in 5 countries.
Funding
Abstract
objectiveAn attempt to define pre-osteoarthritis (OA) versus early OA and definitive osteoarthritis.
methodsA group of specialists in the field of cartilage science and treatment was formed to consider the nature of OA onset and its possible diagnosis.
resultsLate-stage OA, necessitating total joint replacement, is the end stage of a biological process, with many previous earlier stages. Early-stage OA has been defined and involves structural changes identified by arthroscopy or radiography. The group argued that before the "early-stage OA" there must exist a stage where cellular processes, due to the presence of risk factors, have kicked into action but have not yet resulted in structural changes. The group suggested that this stage could be called "pre-osteoarthritis" (pre-OA).
conclusionsThe group suggests that defining points of initiation for OA in the knee could be defined, for example, by traumatic episodes or surgical meniscectomy. Such events may set in motion metabolic processes that could be diagnosed by modern MRI protocols or arthroscopy including probing techniques before structural changes of early OA have developed. Preventive measures should preferably be applied at this pre-OA stage in order to stop the projected OA "epidemic."
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.