ReviewFrontiers in genetics2015
The use of comet assay in plant toxicology: recent advances.
Review in Frontiers in genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Genotoxic and Physiological Responses to Repeated Exposure to Low-Concentration Silver Nanoparticles inInternational journal of molecular sciences · 2026Article
- Application of Allium cepa Test for Genetic Toxicology.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Micronucleus Assay with Tetrad Cells of Tradescantia.Methods in molecular biology (Clifton, N.J.) · 2026Article
- High Dose of Nickel Unbalances Carbon Metabolism and Nitrogen Assimilation in Barley (Plants (Basel, Switzerland) · 2025Article
- TheMethods and protocols · 2025Review
- Molecular, biophysical, and biochemical studies on irradiated Zea mays seeds using various sources of gamma rays for dosimetrical applications.Scientific reports · 2025Article
- Multi-taxon trends and the application of genotoxic biomarkers in the analysis of effluents from sewage treatment plant.Heliyon · 2023Review
- Article
- Metformin Protects Radiation-Induced Early Brain Injury by Reducing Inflammation and DNA Damage.Brain sciences · 2023Article
- Measuring DNA modifications with the comet assay: a compendium of protocols.Nature protocols · 2023Review
- Potential Use ofPharmaceutics · 2023Article
- Determination of genotoxic damages of picloram and dicamba with comet assay in Allium cepa rooted in tissue culture and distilled water.Molecular biology reports · 2022Article
- Nanomaterials Induced Genotoxicity in Plant: Methods and Strategies.Nanomaterials (Basel, Switzerland) · 2022Review
- DNA integrity and ecophysiological responses of Spanish populations of Ulmus glabra to increasing ozone levels.Ecotoxicology (London, England) · 2021Article
- Plant Recovery after Metal Stress-A Review.Plants (Basel, Switzerland) · 2021Review
- Evaluation of copper-induced DNA damage in Vitis vinifera L. using Comet-FISH.Environmental science and pollution research international · 2021Article
- Review
- Comet assay: a versatile but complex tool in genotoxicity testing.Toxicology research · 2021Review
- Protoplast: A Valuable Toolbox to Investigate Plant Stress Perception and Response.Frontiers in plant science · 2021Review
- Complete Chromatin Decondensation of Pig Sperm Is Required to Analyze Sperm DNA Breaks With the Comet Assay.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The systematic study of genotoxicity in plants induced by contaminants and other stress agents has been hindered to date by the lack of reliable and robust biomarkers. The comet assay is a versatile and sensitive method for the evaluation of DNA damages and DNA repair capacity at single-cell level. Due to its simplicity and sensitivity, and the small number of cells required to obtain robust results, the use of plant comet assay has drastically increased in the last decade. For years its use was restricted to a few model species, e.g., Allium cepa, Nicotiana tabacum, Vicia faba, or Arabidopsis thaliana but this number largely increased in the last years. Plant comet assay has been used to study the genotoxic impact of radiation, chemicals including pesticides, phytocompounds, heavy metals, nanoparticles or contaminated complex matrices. Here we will review the most recent data on the use of this technique as a standard approach for studying the genotoxic effects of different stress conditions on plants. Also, we will discuss the integration of information provided by the comet assay with other DNA-damage indicators, and with cellular responses including oxidative stress, cell division or cell death. Finally, we will focus on putative relations between transcripts related with DNA damage pathways, DNA replication and repair, oxidative stress and cell cycle progression that have been identified in plant cells with comet assays demonstrating DNA damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.