Evidence map›Paper›PMID 26175728›Full record

ReviewFrontiers in microbiology2015

Role of gut microbiota in the modulation of atherosclerosis-associated immune response.

Dmitry A Chistiakov, Yuri V Bobryshev, Emil Kozarov, Igor A Sobenin, Alexander N Orekhov

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.

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  7. Reduced abundance ofFrontiers in pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Dmitry A ChistiakovDepartment of Molecular Genetic Diagnostics and Cell Biology, Division of Laboratory Medicine, Institute of Pediatrics, Research Center for Children's Health, Moscow Russia ; The Mount Sinai Community Clinical Oncology Program, Mount Sinai Comprehensive Cancer Center, Mount Sinai Medical Center, Miami Beach, FL USA.
Yuri V BobryshevLaboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow Russia ; Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, NSW Australia ; School of Medicine, University of Western Sydney, Campbelltown, NSW Australia.
Emil KozarovDepartment of Oral and Diagnostic Sciences, Columbia University, New York, NY USA.
Igor A SobeninLaboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow Russia ; Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow Russia.
Alexander N OrekhovLaboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow Russia ; Institute for Atherosclerosis, Skolkovo Innovation Center, Moscow Russia ; Department of Biophysics, Biological Faculty, Moscow State University, Moscow Russia.
Columbia University · USLomonosov Moscow State University · RUMount Sinai Medical Center · USResearch Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RUWestern Sydney University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation and metabolic abnormalities are linked to each other. At present, pathogenic inflammatory response was recognized as a major player in metabolic diseases. In humans, intestinal microflora could significantly influence the development of metabolic diseases including atherosclerosis. Commensal bacteria were shown to activate inflammatory pathways through altering lipid metabolism in adipocytes, macrophages, and vascular cells, inducing insulin resistance, and producing trimethylamine-N-oxide. However, gut microbiota could also play the atheroprotective role associated with anthocyanin metabolism and administration of probiotics and their components. Here, we review the mechanisms by which the gut microbiota may influence atherogenesis.

Indexed as

arteriesatherogenesisatherosclerosisimmune systemintestinal microbiota

Identifiers

PMID26175728
PMCPMC4485310
OpenAlexW1582041820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.