ReviewFrontiers in neuroscience2015
Parasites and steroid hormones: corticosteroid and sex steroid synthesis, their role in the parasite physiology and development.
Review in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Disturbance in human gut microbiota networks by parasites and its implications in the incidence of depression.Scientific reports · 2020Trial
- Drug Repurposing in Parasitology: New Uses for Old Drugs to Be Used Through the Host-Parasite Interface.Pathogens (Basel, Switzerland) · 2026Review
- Neurocysticercosis Is the Result of the Interplay between Parasites, Hormones, and Inflammation.Neuroimmunomodulation · 2026Review
- Tannin alleviated reproductive dysfunction in pregnant ewes infected withFrontiers in veterinary science · 2025Article
- Host selection and influencing factors of parasitic fleas on the body surface of desert rodents, Inner Mongolia, China.International journal for parasitology. Parasites and wildlife · 2024Article
- The Sexual Dimorphism of the Neuroimmune Response in the Brains ofBrain sciences · 2024Article
- Murine Extraparenchymal Neurocysticercosis: Appropriate Model for Evaluating Anthelminthic and Anti-Inflammatory Treatment Schedules.Tropical medicine and infectious disease · 2024Article
- Current Role of Surgery in the Treatment of Neurocysticercosis.Pathogens (Basel, Switzerland) · 2024Review
- Influence of sexual hormones on Chagas disease.Archivos de cardiologia de Mexico · 2024Article
- Unusual cholesterol crystal formation in a rare clinical case report of splenic echinococcal cyst in a patient from Sardinia, Italy.Frontiers in parasitology · 2024Article
- A NovelMicroorganisms · 2023Article
- Parasite effects on receivers in animal communication: Hidden impacts on behavior, ecology, and evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- New metabolic signature for Chagas disease reveals sex steroid perturbation in humans and mice.Heliyon · 2022Article
- Sex-the most underappreciated variable in research: insights from helminth-infected hosts.Veterinary research · 2022Review
- Splenic hydatid disease in pregnancy.Southern African journal of HIV medicine · 2022Article
- Description and Molecular Characterization of Two Species of Avian Blood Parasites, with Remarks on Circadian Rhythms of Avian Haematozoa Infections.Animals : an open access journal from MDPI · 2021Article
- Predictors of helminth parasite infection in female chacma baboons (International journal for parasitology. Parasites and wildlife · 2021Article
- Sex Steroid Hormones as a Balancing Factor in Oral Host Microbiome Interactions.Frontiers in cellular and infection microbiology · 2021Review
- Strongyloides stercoralis and other intestinal parasites in patients receiving immunosuppressive drugs in northern Iran: a closer look at risk factors.Epidemiology and health · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many cases parasites display highly complex life cycles that include the penetration and permanence of the larva or adults within host organs, but even in those that only have one host, reciprocal, intricate interactions occur. Evidence indicates that steroid hormones have an influence on the development and course of parasitic infections. The host gender's susceptibility to infection, and the related differences in the immune response are good examples of the host-parasite interplay. However, the capacity of these organisms to synthesize their own steroidogenic hormones still has more questions than answers. It is now well-known that many parasites synthesize ecdysteroids, but limited information is available on sex steroid and corticosteroid synthesis. This review intends to summarize some of the existing information in the field. In most, but not all parasitosis the host's hormonal environment determines the susceptibility, the course, and severity of parasite infections. In most cases the infection disturbs the host environment, and activates immune responses that end up affecting the endocrine system. Furthermore, sex steroids and corticosteroids may also directly modify the parasite reproduction and molting. Available information indicates that parasites synthesize some steroid hormones, such as ecdysteroids and sex steroids, and the presence and activity of related enzymes have been demonstrated. More recently, the synthesis of corticosteroid-like compounds has been shown in Taenia solium cysticerci and tapeworms, and in Taenia crassiceps WFU cysticerci. In-depth knowledge of the parasite's endocrine properties will contribute to understand their reproduction and reciprocal interactions with the host, and may also help designing tools to combat the infection in some clinical situations.
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