Evidence map›Paper›PMID 26175657›Full record

ReviewJournal of the International Society of Sports Nutrition2015

International society of sports nutrition position stand: Beta-Alanine.

Eric T Trexler, Abbie E Smith-Ryan, Jeffrey R Stout, Jay R Hoffman, Colin D Wilborn, Craig Sale, Richard B Kreider, Ralf Jäger, Conrad P Earnest, Laurent Bannock and 4 more

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the International Society of Sports Nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05096793 (Acute Supplementation With Beta-Alanine Improves Performance in Aerobic-anaerobic Transition Zones in Endurance Athletes), which is not on this map. Cited by 138 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 13 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05096793 nacompletednot on this mapstarted 2021, after this paper: background citation

Acute Supplementation With Beta-Alanine Improves Performance in Aerobic-anaerobic Transition Zones in Endurance Athletes

TypeinterventionalSponsorUniversity of AmericasRan2021 to 2021Enrolled12ConditionsBeta-alanineArmsbeta alanine
3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 13 syntheses or guidelines pooled it, 281 citations in OpenAlex.

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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Eric T Trexler *Applied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, NC USA.
Abbie E Smith-Ryan *Applied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, NC USA.
Jeffrey R StoutDepartment of Sport and Exercise Science, University of Central Florida, Orlando, FL USA.
Jay R HoffmanDepartment of Sport and Exercise Science, University of Central Florida, Orlando, FL USA.
Colin D WilbornHuman Performance Laboratory, Department of Exercise Science, University of Mary Hardin-Baylor, Belton, TX USA.
Craig SaleHealth and Performance Enhancement Research Centre, Department of Sport Science, Nottingham Trent University, Nottingham, UK.
Richard B KreiderExercise & Sport Nutrition Lab, Department of Health & Kinesiology, Texas A&M University, College Station, TX USA.
Ralf JägerIncrenovo LLC, 2138 E Lafayette Pl, Milwaukee, WI USA.
Conrad P EarnestExercise & Sport Nutrition Lab, Department of Health & Kinesiology, Texas A&M University, College Station, TX USA.
Laurent BannockGuru Performance LTD, London, UK.
Bill CampbellPerformance & Physique Enhancement Laboratory, University of South Florida, Tampa, FL USA.
Douglas KalmanDepartment of Nutrition & Endocrinology, Miami Research Associates, QPS-MRA, Miami, FL USA.
Tim N ZiegenfussThe Center for Applied Health Sciences, 4302 Allen Rd, STE 120 Stow, OH USA.
Jose AntonioExercise and Sports Science, Nova Southeastern University, Davie, FL USA.
Texas A&M University · USUniversity of Central Florida · USGuru Performance (United Kingdom) · GBNottingham Trent University · GBNova Southeastern University · USUniversity of Mary Hardin–Baylor · USUniversity of North Carolina at Chapel Hill · USUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The International Society of Sports Nutrition (ISSN) provides an objective and critical review of the mechanisms and use of beta-alanine supplementation. Based on the current available literature, the conclusions of the ISSN are as follows: 1) Four weeks of beta-alanine supplementation (4-6 g daily) significantly augments muscle carnosine concentrations, thereby acting as an intracellular pH buffer; 2) Beta-alanine supplementation currently appears to be safe in healthy populations at recommended doses; 3) The only reported side effect is paraesthesia (tingling), but studies indicate this can be attenuated by using divided lower doses (1.6 g) or using a sustained-release formula; 4) Daily supplementation with 4 to 6 g of beta-alanine for at least 2 to 4 weeks has been shown to improve exercise performance, with more pronounced effects in open end-point tasks/time trials lasting 1 to 4 min in duration; 5) Beta-alanine attenuates neuromuscular fatigue, particularly in older subjects, and preliminary evidence indicates that beta-alanine may improve tactical performance; 6) Combining beta-alanine with other single or multi-ingredient supplements may be advantageous when supplementation of beta-alanine is high enough (4-6 g daily) and long enough (minimum 4 weeks); 7) More research is needed to determine the effects of beta-alanine on strength, endurance performance beyond 25 min in duration, and other health-related benefits associated with carnosine.

Indexed as

Sports Nutritional Physiological Phenomenabeta-AlanineCarnosineDietary SupplementsDose-Response Relationship, DrugExerciseFatigueHumansHydrogen-Ion ConcentrationMuscle, SkeletalNeuromuscular AgentsRecommended Dietary AllowancesToxicity Testsbeta-AlanineCarnosineNeuromuscular Agents

Identifiers

PMID26175657
PMCPMC4501114
OpenAlexW1915320120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.