Evidence map›Paper›PMID 26175594›Full record

ArticleKorean journal of radiology

Detection of Myocardial Metabolic Abnormalities by 18F-FDG PET/CT and Corresponding Pathological Changes in Beagles with Local Heart Irradiation.

Rui Yan, Jianbo Song, Zhifang Wu, Min Guo, Jianzhong Liu, Jianguo Li, Xinzhong Hao, Sijin Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Korean journal of radiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  12. Trastuzumab aggravates radiation induced cardiotoxicity in mice.American journal of cancer research · 2022
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  19. Multimodality Cardiac Imaging in the Era of Emerging Cancer Therapies.Journal of the American Heart Association · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rui YanNursing College of Shanxi Medical University, Taiyuan 030001, China. ; Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Jianbo SongDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Zhifang WuDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Min GuoDepartment of Cardiology, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Jianzhong LiuDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Jianguo LiDepartment of Radiological and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.
Xinzhong HaoDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Sijin LiDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Shanxi Medical University · CNFirst Hospital of Shanxi Medical University · CNNational Institute for Radiological Protection · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the efficacy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the detection of radiation-induced myocardial damage in beagles by comparing two pre-scan preparation protocols as well as to determine the correlation between abnormal myocardial FDG uptake and pathological findings. MATERIALS AND

methodsThe anterior myocardium of 12 beagles received radiotherapy locally with a single X-ray dose of 20 Gy. 18F-FDG cardiac PET/CT was performed at baseline and 3 months after radiation. Twelve beagles underwent two protocols before PET/CT: 12 hours of fasting (12H-F), 12H-F followed by a high-fat diet (F-HFD). Regions of interest were drawn on the irradiation and the non-irradiation fields to obtain their maximal standardized uptake values (SUVmax). Then the ratio of the SUV of the irradiation to the non-irradiation fields (INR) was computed. Histopathological changes were identified by light and electron microscopy.

resultsUsing the 12H-F protocol, the average INRs were 1.18 ± 0.10 and 1.41 ± 0.18 before and after irradiation, respectively (p = 0.021). Using the F-HFD protocol, the average INRs were 0.99 ± 0.15 and 2.54 ± 0.43, respectively (p < 0.001). High FDG uptake in irradiation field was detected in 33.3% (4/12) of 12H-F protocol and 83.3% (10/12) of F-HFD protocol in visual analysis, respectively (p = 0.031). The pathology of the irradiated myocardium showed obvious perivascular fibrosis and changes in mitochondrial vacuoles.

conclusionHigh FDG uptake in an irradiated field may be related with radiation-induced myocardial damage resulting from microvascular damage and mitochondrial injury. An F-HFD preparation protocol used before obtaining PET/CT can improve the sensitivity of the detection of cardiotoxicity associated with radiotherapy.

Indexed as

AnimalsDogsFastingFluorodeoxyglucose F18HeartHeart InjuriesMaleMyocardiumPositron-Emission TomographyRadiation InjuriesThoracic NeoplasmsTomography, X-Ray ComputedFluorodeoxyglucose F1818F-FDG PET/CTPathologyRadiation-induced heart diseaseRadiotherapy

Identifiers

PMID26175594
PMCPMC4499559
OpenAlexW1693541208

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.