Evidence map›Paper›PMID 26175580›Full record

ArticleKorean journal of radiology

CT Perfusion Imaging Can Predict Patients' Survival and Early Response to Transarterial Chemo-Lipiodol Infusion for Liver Metastases from Colorectal Cancers.

Wei-Fu Lv, Jian-Kui Han, De-Lei Cheng, Chun-Ze Zhou, Ming Ni, Dong Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Korean journal of radiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. A Systematic Review on the Role of the Perfusion Computed Tomography in Abdominal Cancer.Dose-response : a publication of International Hormesis Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Wei-Fu LvPET/CT Center, Qilu Hospital, First Affiliated Hospital of Shandong University, Jinan 250012, China. ; Department of Radiology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China.
Jian-Kui HanPET/CT Center, Qilu Hospital, First Affiliated Hospital of Shandong University, Jinan 250012, China.
De-Lei ChengDepartment of Radiology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China.
Chun-Ze ZhouDepartment of Radiology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China.
Ming NiDepartment of Radiology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China.
Dong LuDepartment of Radiology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China.
Anhui Provincial Hospital · CNShandong University · CNAnhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo prospectively evaluate the performance of computed tomography perfusion imaging (CTPI) in predicting the early response to transarterial chemo-lipiodol infusion (TACLI) and survival of patients with colorectal cancer liver metastases (CRLM). MATERIALS AND

methodsComputed tomography perfusion imaging was performed before and 1 month after TACLI in 61 consecutive patients. Therapeutic response was evaluated on CT scans 1 month and 4 months after TACLI; the patients were classified as responders and non-responders based on 4-month CT scans after TACLI. The percentage change of CTPI parameters of target lesions were compared between responders and non-responders at 1 month after TACLI. The optimal parameter and cutoff value were determined. The patients were divided into 2 subgroups according to the cutoff value. The log-rank test was used to compare the survival rates of the 2 subgroups.

resultsFour-month images were obtained from 58 patients, of which 39.7% were responders and 60.3% were non-responders. The percentage change in hepatic arterial perfusion (HAP) 1 month after TACLI was the optimal predicting parameter (p = 0.003). The best cut-off value was -21.5% and patients who exhibited a ≥ 21.5% decrease in HAP had a significantly higher overall survival rate than those who exhibited a < 21.5% decrease (p < 0.001).

conclusionComputed tomography perfusion imaging can predict the early response to TACLI and survival of patients with CRLM. The percentage change in HAP after TACLI with a cutoff value of -21.5% is the optimal predictor.

Indexed as

AdultAgedColorectal NeoplasmsContrast MediaEthiodized OilFemaleHepatic ArteryHumansLiver NeoplasmsMaleMiddle AgedPerfusion ImagingProspective StudiesSurvival RateTomography, X-Ray ComputedContrast MediaEthiodized OilColorectal cancerComputed tomography perfusion imagingLiverMetastatic carcinomaTransarterial chemo-lipiodol infusion

Identifiers

PMID26175580
PMCPMC4499545
OpenAlexW1763562290

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.