ArticleThe Plant cell2015
A Selaginella moellendorffii Ortholog of KARRIKIN INSENSITIVE2 Functions in Arabidopsis Development but Cannot Mediate Responses to Karrikins or Strigolactones.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 143 citations in OpenAlex.
- Hormone-metabolism crosstalk in plants: an integrated signaling network coordinating growth and stress adaptation.Plant signaling & behavior · 2026Review
- Negative feedback regulation of karrikin signaling inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural and functional characterisation of a reconstructed ancestral strigolactone receptor.The Plant journal : for cell and molecular biology · 2026Article
- Divergent strigolactones or karrikins signaling is mediated by preferred AtD14/KAI2-MAX2-SMXL complex targeting specific SMXL domains.iScience · 2026Article
- Molecular insights into volatile organic compound sensing and signaling in plants.The Plant journal : for cell and molecular biology · 2026Review
- Overexpression of DWARF14-LIKE2 in Arabidopsis thaliana alters multiple traits related to plant morphology and osmotic and salt stress tolerance.Plant cell reports · 2026Article
- Smoke water and smoke-derived karrikinolide, KARScientific reports · 2026Article
- In vitro dynamic and quantitative monitoring of strigolactone-signaling complex formation by time-resolved FRET.The Plant journal : for cell and molecular biology · 2025Article
- The Multifaceted Impact of Karrikin Signaling in Plants.International journal of molecular sciences · 2025Review
- Structural requirements of KAI2 ligands for activation of signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- SUPPRESSOR OF MAX2 1-LIKE (SMXL) homologs are MAX2-dependent repressors of Physcomitrium patens growth.The Plant cell · 2024Article
- Identification of osmotic stress resistance mediated byFrontiers in plant science · 2024Article
- KAI2 Can Do: Karrikin Receptor Function in Plant Development and Response to Abiotic and Biotic Factors.Plant & cell physiology · 2023Article
- Activation of Strigolactone Biosynthesis by the DWARF14-LIKE/KARRIKIN-INSENSITIVE2 Pathway in Mycorrhizal Angiosperms, but Not in Arabidopsis, a Non-mycorrhizal Plant.Plant & cell physiology · 2023Article
- Impact of Intron and Retransformation on Transgene Expression in Leaf and Fruit Tissues of Field-Grown Pear Trees.International journal of molecular sciences · 2023Article
- Structural analysis of a hormone-bound Striga strigolactone receptor.Nature plants · 2023Article
- Identification of a candidate dwarfing gene in Pallas, the first commercial barley cultivar generated through mutational breeding.Frontiers in genetics · 2023Article
- KARRIKIN UPREGULATED F-BOX 1 negatively regulates drought tolerance in Arabidopsis.Plant physiology · 2022Article
- A KARRIKIN INSENSITIVE2 paralog in lettuce mediates highly sensitive germination responses to karrikinolide.Plant physiology · 2022Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Arabidopsis thaliana, the α/β-fold hydrolase KARRIKIN INSENSITIVE2 (KAI2) is essential for normal seed germination, seedling development, and leaf morphogenesis, as well as for responses to karrikins. KAI2 is a paralog of DWARF14 (D14), the proposed strigolactone receptor, but the evolutionary timing of functional divergence between the KAI2 and D14 clades has not been established. By swapping gene promoters, we show that Arabidopsis KAI2 and D14 proteins are functionally distinct. We show that the catalytic serine of KAI2 is essential for function in plants and for biochemical activity in vitro. We identified two KAI2 homologs from Selaginella moellendorffii and two from Marchantia polymorpha. One from each species could hydrolyze the strigolactone analog GR24 in vitro, but when tested for their ability to complement Arabidopsis d14 and kai2 mutants, neither of these homologs was effective. However, the second KAI2 homolog from S. moellendorffii was able to complement the seedling and leaf development phenotypes of Arabidopsis kai2. This homolog could not transduce signals from exogenous karrikins, strigolactone analogs, or carlactone, but its activity did depend on the conserved catalytic serine. We conclude that KAI2, and most likely the endogenous signal to which it responds, has been conserved since the divergence of lycophytes and angiosperm lineages, despite their major developmental and morphogenic differences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.