Evidence map›Paper›PMID 26175491›Full record

ArticleScience signaling2015

The rise in computational systems biology approaches for understanding NF-κB signaling dynamics.

Richard A Williams, Jon Timmis, Eva E Qwarnstrom

Abstract readComment
PubMed Publisher
In one paragraph

Article in Science signaling, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The IL-1RI Co-Receptor TILRR (JACC. Basic to translational science · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Richard A WilliamsSimulation Group, Department of Management Science, Lancaster University, Lancaster LA1 4YX, UK. r.williams4@lancaster.ac.uk.
Jon TimmisDepartment of Electronics, University of York, Heslington, York YO10 5DD, UK. York Computational Immunology Laboratory, University of York, Heslington, York YO10 5DD, UK.
Eva E QwarnstromDepartment of Cardiovascular Science, Sheffield University Medical School, Sheffield S10 2RX, UK. Department of Pathology, University of Washington, Seattle, WA 98195, USA.

Funding

Biotechnology and Biological Sciences Research Council BB/C515798/1Biotechnology and Biological Sciences Research Council BB/J009687/1British Heart Foundation PG/11/103/29219Medical Research Council MC_PC_13076Wellcome Trust 097829
6 · The paper itself

Abstract

A study by Cheng et al. in this issue of Science Signaling highlights the distinct single-cell signaling characteristics conferred by pathways mediated by the adaptor proteins MyD88 and TRIF in the TLR4-dependent activation of the transcription factor nuclear factor κB (NF-κB).

Indexed as

Adaptor Proteins, Vesicular TransportAnimalsMyeloid Differentiation Factor 88Signal TransductionToll-Like Receptor 4Adaptor Proteins, Vesicular TransportMyeloid Differentiation Factor 88Toll-Like Receptor 4

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.