ArticleThe Journal of infectious diseases2016
Identifying Hotspots of Multidrug-Resistant Tuberculosis Transmission Using Spatial and Molecular Genetic Data.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Spatially targeted screening to reduce tuberculosis transmission in high-incidence settings.The Lancet. Infectious diseases · 2019Pooled it
- Methods used in the spatial analysis of tuberculosis epidemiology: a systematic review.BMC medicine · 2018Pooled it
- Quantifying the community transmission ofEmerging microbes & infections · 2026Article
- Article
- A retrospective analysis of tuberculosis notification trends and spatial distribution in South Africa, 2005-2012.Discover public health · 2026Article
- Spatial Distribution of COVID-19 Diagnostic Services in Mopani District, Limpopo Province, South Africa.Public health challenges · 2025Article
- Geographical location and genotyping analysis of pulmonary tuberculosis in the state of Nuevo Leon, Mexico.Scientific reports · 2025Article
- Type VII secretion system gene mutations driving global mycobacterium tuberculosis transmission revealed by whole genomic sequence.Frontiers in cellular and infection microbiology · 2025Article
- Distribution and transmission of M. tuberculosis in a high-HIV prevalence city in Malawi: A genomic and spatial analysis.PLOS global public health · 2025Article
- Transmission of tuberculosis in rural Henan, China: a prospective population-based genomic spatial epidemiological study.Emerging microbes & infections · 2024Article
- Genomic analysis of lineage-specific transmission of multidrug resistance tuberculosis in China.Emerging microbes & infections · 2024Article
- Modeling tuberculosis transmission flow in China, 2010-2012.BMC infectious diseases · 2024Article
- Observational
- Identification of Risk Factors Associated with Tuberculosis in Southwest Iran: A Machine Learning Method.Medical journal of the Islamic Republic of Iran · 2024Article
- Genomic and Spatial Analysis on the Recent Transmission ofInfection and drug resistance · 2024Article
- Integrating Molecular Diagnostics and GIS Mapping: A Multidisciplinary Approach to Understanding Tuberculosis Disease Dynamics in South Africa Using Xpert MTB/RIF.Diagnostics (Basel, Switzerland) · 2023Article
- Genotypic and spatial analysis of transmission dynamics of tuberculosis in Shanghai, China: a 10-year prospective population-based surveillance study.The Lancet regional health. Western Pacific · 2023Article
- Investigating the intensity of social contacts associated with tuberculosis: a weighted networks model.BMC pulmonary medicine · 2023Article
- Polyketide synthases mutation in tuberculosis transmission revealed by whole genomic sequence, China, 2011-2019.Frontiers in genetics · 2023Article
- Social Contact Patterns Associated With Tuberculosis: A Case-control Study in Southwest Iran.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2022Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundWe aimed to identify and determine the etiology of "hotspots" of concentrated multidrug-resistant tuberculosis (MDR-tuberculosis) risk in Lima, Peru.
methodsFrom 2009 to 2012, we conducted a prospective cohort study among households of tuberculosis cases from 106 health center (HC) areas in Lima, Peru. All notified tuberculosis cases and their household contacts were followed for 1 year. Symptomatic individuals were screened by microscopy and culture; positive cultures were tested for drug susceptibility (DST) and genotyped by 24-loci mycobacterial interspersed repetitive units-variable-number tandem repeats (MIRU-VNTR).
results3286 individuals with culture-confirmed disease, DST, and 24-loci MIRU-VNTR were included in our analysis. Our analysis reveals: (1) heterogeneity in annual per-capita incidence of tuberculosis and MDR-tuberculosis by HC, with a rate of MDR-tuberculosis 89 times greater (95% confidence interval [CI], 54,185) in the most-affected versus the least-affected HC; (2) high risk for MDR-tuberculosis in a region spanning several HCs (odds ratio = 3.19, 95% CI, 2.33, 4.36); and (3) spatial aggregation of MDR-tuberculosis genotypes, suggesting localized transmission.
conclusionsThese findings reveal that localized transmission is an important driver of the epidemic of MDR-tuberculosis in Lima. Efforts to interrupt transmission may be most effective if targeted to this area of the city.
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Registered trials
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