ArticleMethods in cell biology2015
Centriole biogenesis and function in multiciliated cells.
Article in Methods in cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Molecular architecture of the ciliary base in mammalian multiciliated cells.bioRxiv : the preprint server for biology · 2026Article
- JNK regulates ciliogenesis through the interflagellar transport complex and actin networks.The Journal of cell biology · 2023Article
- Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery.EMBO reports · 2022Article
- Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells.eLife · 2021Article
- A role for Cep70 in centriole amplification in multiciliated cells.Developmental biology · 2021Article
- Unraveling spatial cellular pattern by computational tissue shuffling.Communications biology · 2020Article
- WDR5 Stabilizes Actin Architecture to Promote Multiciliated Cell Formation.Developmental cell · 2018Article
- CLAMP/Spef1 regulates planar cell polarity signaling and asymmetric microtubule accumulation in theThe Journal of cell biology · 2018Article
- What we can learn from a tadpole about ciliopathies and airway diseases: Using systems biology in Xenopus to study cilia and mucociliary epithelia.Genesis (New York, N.Y. : 2000) · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The use of Xenopus embryonic skin as a model system for the development of ciliated epithelia is well established. This tissue is comprised of numerous cell types, most notably the multiciliated cells (MCCs) that each contain approximately 150 motile cilia. At the base of each cilium lies the centriole-based structure called the basal body. Centriole biogenesis is typically restricted to two new centrioles per cell cycle, each templating from an existing "mother" centriole. In contrast, MCCs are post-mitotic cells in which the majority of centrioles arise "de novo" without templating from a mother centriole, instead, these centrioles nucleate from an electron-dense structure termed the deuterostome. How centriole number is regulated in these cells and the mechanism by which the deuterosome templates nascent centrioles is still poorly understood. Here, we describe methods for regulating MCC cell fate as well as for visualizing and manipulating centriole biogenesis.
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