ArticleInternational journal of cancer2016
Phylogenetic analysis of multiple FISH markers in oral tongue squamous cell carcinoma suggests that a diverse distribution of copy number changes is associated with poor prognosis.
Article in International journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Pooled it
- Regulation of dendrite growth by Cdc42 effector protein‑4 in hippocampal neuronsMolecular medicine reports · 2022Article
- Detection of cytogenetic changes and chromosomal aneuploidy with fluorescent in situ hybridization in cytological specimens of oral cancers in Fanconi anemia-Proof of concept.Clinical and experimental dental research · 2022Article
- Assessing the contribution of tumor mutational phenotypes to cancer progression risk.PLoS computational biology · 2021Article
- High Levels of Chromosomal Copy Number Alterations and TP53 Mutations Correlate with Poor Outcome in Younger Breast Cancer Patients.The American journal of pathology · 2020Article
- Single-cell genetic analysis of clonal dynamics in colorectal adenomas indicates CDX2 gain as a predictor of recurrence.International journal of cancer · 2019Article
- Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2019Article
- EphA8 is a Prognostic Factor for Oral Tongue Squamous Cell Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Classifying the evolutionary and ecological features of neoplasms.Nature reviews. Cancer · 2017Review
- A population genetics perspective on the determinants of intra-tumor heterogeneity.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- The evolution of tumour phylogenetics: principles and practice.Nature reviews. Genetics · 2017Review
- Evolutionary scalpels for dissecting tumor ecosystems.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- FISHtrees 3.0: Tumor Phylogenetics Using a Ploidy Probe.PloS one · 2016Article
Corrections and comments
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Authors and funding
14 authors at 12 institutions in 3 countries.
Funding
Abstract
Oral tongue squamous cell carcinoma (OTSCC) is associated with poor prognosis. To improve prognostication, we analyzed four gene probes (TERC, CCND1, EGFR and TP53) and the centromere probe CEP4 as a marker of chromosomal instability, using fluorescence in situ hybridization (FISH) in single cells from the tumors of sixty-five OTSCC patients (Stage I, n = 15; Stage II, n = 30; Stage III, n = 7; Stage IV, n = 13). Unsupervised hierarchical clustering of the FISH data distinguished three clusters related to smoking status. Copy number increases of all five markers were found to be correlated to non-smoking habits, while smokers in this cohort had low-level copy number gains. Using the phylogenetic modeling software FISHtrees, we constructed models of tumor progression for each patient based on the four gene probes. Then, we derived test statistics on the models that are significant predictors of disease-free and overall survival, independent of tumor stage and smoking status in multivariate analysis. The patients whose tumors were modeled as progressing by a more diverse distribution of copy number changes across the four genes have poorer prognosis. This is consistent with the view that multiple genetic pathways need to become deregulated in order for cancer to progress.
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Registered trials
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