Evidence map›Paper›PMID 26175216›Full record

ArticleScientific reports2015

Biomarkers of delayed graft function as a form of acute kidney injury in kidney transplantation.

Jolanta Malyszko, Ewelina Lukaszyk, Irena Glowinska, Magdalena Durlik

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Kidney Transplantation From Donors With Acute Kidney Injury: Are the Concerns Justified? A Systematic Review and Meta-Analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Proenkephalin A 119-159 in Kidney Transplantation: A Novel Biomarker for Superior Tracking of Graft Function Trajectories.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jolanta Malyszko2nd Department of Nephrology, Medical University, Bialystok, Poland.
Ewelina Lukaszyk2nd Department of Nephrology, Medical University, Bialystok, Poland.
Irena Glowinska2nd Department of Nephrology, Medical University, Bialystok, Poland.
Magdalena DurlikDepartment of Nephrology and Transplantation Medicine, Warsaw Medical University, Poland.
Medical University of Białystok · PLMedical University of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal transplantation ensures distinct advantages for patients with end-stage kidney disease. However, in some cases early complications can lead to allograft dysfunction and consequently graft loss. One of the most common early complications after kidney transplantation is delayed graft function (DGF). Unfortunately there is no effective treatment for DGF, however early diagnosis of DGF and therapeutic intervention (eg modification of immunosuppression) may improve outcome. Therefore, markers of acute kidney injury are required. Creatinine is a poor biomarker for kidney injury due principally to its inability to help diagnose early acute renal failure and complete inability to help differentiate among its various causes. Different urinary and serum proteins have been intensively investigated as possible biomarkers in this setting. There are promising candidate biomarkers with the ability to detect DGF. We focused on emerging biomarkers of DGF with NGAL is being the most studied followed by KIM-1, L-FABP, IL-18, and others. However, large randomized studies are needed to establish the value of new, promising biomarkers, in DGF diagnosis, prognosis and its cost-effectiveness.

Indexed as

Kidney TransplantationAcute Kidney InjuryAcute-Phase ProteinsAdipokinesBiomarkersChitinase-3-Like Protein 1ClusterinCreatinineCystatin CDelayed Graft FunctionFatty Acid-Binding ProteinsHepatitis A Virus Cellular Receptor 1HumansInterleukin-18LectinsLipocalin-2Acute-Phase ProteinsAdipokinesBiomarkersCHI3L1 protein, humanChitinase-3-Like Protein 1ClusterinCreatinineCystatin CFABP1 protein, humanFatty Acid-Binding ProteinsHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1Interleukin-18LCN2 protein, humanLectinsLipocalin-2LipocalinsMembrane GlycoproteinsProto-Oncogene ProteinsReceptors, Virus

Identifiers

PMID26175216
PMCPMC4502393
OpenAlexW2264886704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.