ArticleJournal of biomedical materials research. Part B, Applied biomaterials2016
Dehydrated human amnion/chorion membrane regulates stem cell activity in vitro.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Palatal donor site wound healing following mucogingival surgery using amnion-chorion membrane: A randomized controlled clinical trial.Journal of periodontology · 2026Trial
- Use of Human Amnion/Chorion Membrane as a Protective Barrier in Complicated Diverticulitis Patients Undergoing Colorectal Resections.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2026Article
- Review
- Real-world outcomes following dehydrated human amnion/chorion membrane use in left-sided colectomy without a protective stoma: a multicenter pilot study.Frontiers in surgery · 2026Article
- Immunomodulatory effects of Purion processed human amniotic membrane allografts in vitro.Journal of inflammation (London, England) · 2025Article
- Refractory ulcers of both legs with psoriasis vulgaris successfully treated with dehydrated human amnion/chorion membrane: A case report.JPRAS open · 2025Article
- Dehydrated Human Amnion-Chorion Membrane as a Bioactive Scaffold for Dental Pulp Tissue Regeneration.Biomimetics (Basel, Switzerland) · 2024Review
- Human amniotic membrane modulates collagen production and deposition in vitro.Scientific reports · 2024Article
- PURIONJournal of biomaterials applications · 2024Article
- Dehydrated human amnion/chorion membrane allograft with spongy layer to significantly improve the outcome of chronic non-healing wounds.International wound journal · 2024Article
- The Preparation and Clinical Efficacy of Amnion-Derived Membranes: A Review.Journal of functional biomaterials · 2023Review
- A split-mouth randomised controlled trial comparing the clinical effects of MVISTA with chorion membrane or connective tissue graft in multiple gingival recessions.The Saudi dental journal · 2023Article
- Dehydrated human amniotic membrane regulates tenocyte expression and angiogenesis in vitro: Implications for a therapeutic treatment of tendinopathy.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Fabrication of Decellularized Amnion and Chorion Scaffolds to Develop Bioengineered Cell-Laden Constructs.Cellular and molecular bioengineering · 2022Article
- Foot Wounds and the Reconstructive Ladder.Plastic and reconstructive surgery. Global open · 2021Article
- Human amniotic membrane modulates Wnt/β-catenin and NF-κβ signaling pathways in articular chondrocytesOsteoarthritis and cartilage open · 2021Article
- Review
- Developing a pro-angiogenic placenta derived amniochorionic scaffold with two exposed basement membranes as substrates for cultivating endothelial cells.Scientific reports · 2021Article
- Dehydrated Human Amniotic Membrane Inhibits Myofibroblast Contraction through the Regulation of the TGFβ‒SMAD Pathway In Vitro.JID innovations : skin science from molecules to population health · 2021Article
- Comprehensive Comparison of Amnion Stromal Cells and Chorion Stromal Cells by RNA-Seq.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human-derived placental tissues have been shown in randomized clinical trials to be effective for healing chronic wounds, and have also demonstrated the ability to recruit stem cells to the wound site in vitro and in vivo. In this study, PURION(®) Processed dehydrated human amnion/chorion membrane allografts (dHACM, EpiFix(®) , MiMedx Group, Marietta, GA) were evaluated for their ability to alter stem cell activity in vitro. Human bone marrow mesenchymal stem cells (BM-MSCs), adipose derived stem cells (ADSCs), and hematopoietic stem cells (HSCs) were treated with soluble extracts of dHACM tissue, and were evaluated for cellular proliferation, migration, and cytokine secretion. Stem cells were analyzed for cell number by DNA assay after 24 h, closure of an acellular zone using microscopy over 3 days, and soluble cytokine production in the medium of treated stem cells was analyzed after 3 days using a multiplex ELISA array. Treatment with soluble extracts of dHACM tissue stimulated BM-MSCs, ADSCs, and HSCs to proliferate with a significant increase in cell number after 24 h. dHACM treatment accelerated closure of an acellular zone by ADSCs and BM-MSCs after 3 days, compared to basal medium. BM-MSCs, ADSCs, and HSCs also modulated endogenous production of a number of various soluble signals, including regulators of inflammation, mitogenesis, and wound healing. dHACM treatment promoted increased proliferation and migration of ADSCs, BM-MSCs, and HSCs, along with modulation of secreted proteins from those cells. Therefore, dHACM may impact wound healing by amplifying host stem cell populations and modulating their responses in treated wound tissues. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1495-1503, 2016.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.