ArticleThe American journal of tropical medicine and hygiene2015
Cost-Effectiveness of Surveillance for Bloodstream Infections for Sepsis Management in Low-Resource Settings.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Costs-effectiveness and cost components of pharmaceutical and non-pharmaceutical interventions affecting antibiotic resistance outcomes in hospital patients: a systematic literature review.BMJ global health · 2024Pooled it
- Resource use, availability and cost in the provision of critical care in Tanzania: a systematic review.BMJ open · 2022Pooled it
- Economic costing methodologies for drug-resistant bacterial infections in humans in low-and middle-income countries: a systematic review.Health economics review · 2025Review
- Cost-effectiveness of maintaining an active hospital microbiology laboratory service in Timor-Leste.The Lancet regional health. Southeast Asia · 2025Article
- The Global Burden of Sepsis and Septic Shock.Epidemiologia (Basel, Switzerland) · 2024Review
- The Impact of the Fungal Priority Pathogens List on Medical Mycology: A Northern European Perspective.Open forum infectious diseases · 2024Review
- Pattern of Antimicrobial Susceptibility and Antimicrobial Treatment of Neonates Admitted with Suspected Sepsis in a Teaching Hospital in Ghana, 2021.International journal of environmental research and public health · 2022Article
- Sepsis among Neonates in a Ghanaian Tertiary Military Hospital: Culture Results and Turnaround Times.International journal of environmental research and public health · 2022Article
- Microbial Distribution and Antibiotic Susceptibility of Bloodstream Infections in Different Intensive Care Units.Frontiers in microbiology · 2021Article
- Bacteremia Among Febrile Patients Attending Selected Healthcare Facilities in Ibadan, Nigeria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Population-based bloodstream infection surveillance in rural Thailand, 2007-2014.BMC public health · 2019Article
- Defining System Requirements for Simplified Blood Culture to Enable Widespread Use in Resource-Limited Settings.Diagnostics (Basel, Switzerland) · 2019Article
- Quantifying the incidence of severe-febrile-illness hospital admissions in sub-Saharan Africa.PloS one · 2019Article
- The epidemiology of febrile illness in sub-Saharan Africa: implications for diagnosis and management.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2018Review
- A Cross-Cutting Approach to Surveillance and Laboratory Capacity as a Platform to Improve Health Security in Uganda.Health security · 2018Article
- Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future.Intensive care medicine · 2017Review
- Evaluating the Trends of Bloodstream Infections among Pediatric and Adult Patients at a Teaching Hospital of Kathmandu, Nepal: Role of Drug Resistant Pathogens.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2017Article
- Neonatal bloodstream infections in a Ghanaian Tertiary Hospital: Are the current antibiotic recommendations adequate?BMC infectious diseases · 2016Article
- Trends in paediatric and adult bloodstream infections at a Ghanaian referral hospital: a retrospective study.Annals of clinical microbiology and antimicrobials · 2016Article
- Fluoroquinolone-Resistant Enteric Bacteria in Sub-Saharan Africa: Clones, Implications and Research Needs.Frontiers in microbiology · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Bacterial sepsis is a leading cause of mortality among febrile patients in low- and middle-income countries, but blood culture services are not widely available. Consequently, empiric antimicrobial management of suspected bloodstream infection is based on generic guidelines that are rarely informed by local data on etiology and patterns of antimicrobial resistance. To evaluate the cost-effectiveness of surveillance for bloodstream infections to inform empiric management of suspected sepsis in low-resource areas, we compared costs and outcomes of generic antimicrobial management with management informed by local data on etiology and patterns of antimicrobial resistance. We applied a decision tree model to a hypothetical population of febrile patients presenting at the district hospital level in Africa. We found that the evidence-based regimen saved 534 more lives per 100,000 patients at an additional cost of $25.35 per patient, resulting in an incremental cost-effectiveness ratio of $4,739. This ratio compares favorably to standard cost-effectiveness thresholds, but should ultimately be compared with other policy-relevant alternatives to determine whether routine surveillance for bloodstream infections is a cost-effective strategy in the African context.
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