ArticleThe Korean journal of parasitology2015
Coexistence of Malaria and Thalassemia in Malaria Endemic Areas of Thailand.
Article in The Korean journal of parasitology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Prevalence of Alpha(α)-Thalassemia in Southeast Asia (2010-2020): A Meta-Analysis Involving 83,674 Subjects.International journal of environmental research and public health · 2020Pooled it
- Health-related quality of life (HRQoL) in beta-thalassemia major (β-TM) patients assessed by 36-item short form health survey (SF-36): a meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Pooled it
- HLA polymorphisms shape divergent outcomes of Toxoplasma and Plasmodium infection in Eastern Indian HbE/β-thalassemia cohort.Communications biology · 2026Article
- Human genetic variations conferring resistance to malaria.Journal of translational medicine · 2025Review
- Changes in Lipid Profile Secondary to Asymptomatic Malaria in Migrants from Sub-Saharan Africa: A Retrospective Analysis of a 2010-2022 Cohort.Tropical medicine and infectious disease · 2025Article
- Analysis of Hematological Parameters in Relation to Genotypes in 497 Patients with Hemoglobin H Disease.International journal of general medicine · 2025Article
- Vivax Malaria and the Potential Role of the Subtelomeric MultigeneMicroorganisms · 2022Review
- Review
- Beta thalassemia minor is a beneficial determinant of red blood cell storage lesion.Haematologica · 2022Article
- A Systematic Review and Meta-Analysis on the Epidemiology of Hepatitis B and Hepatitis C Virus among Beta-Thalassemia Major Patients in Pakistan.Journal of laboratory physicians · 2021Review
- Putative pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations.PLoS neglected tropical diseases · 2021Article
- The Frequency of Beta-Thalassemia Mutations among Carriers in Dezful City, Southwest Iran.Iranian journal of public health · 2020Article
- Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study.Malaria journal · 2020Article
- Consequences ofFrontiers in endocrinology · 2020Article
- Comparison of gene mutation spectrum of thalassemia in different regions of China and Southeast Asia.Molecular genetics & genomic medicine · 2019Article
- Hemoglobin E, malaria and natural selection.Evolution, medicine, and public health · 2019Review
- An Observational Study of the Effect of Hemoglobinopathy, Alpha Thalassemia and Hemoglobin E onMediterranean journal of hematology and infectious diseases · 2018Article
- Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemoglobinopathy and malaria are commonly found worldwide particularly in malaria endemic areas. Thalassemia, the alteration of globin chain synthesis, has been reported to confer resistance against malaria. The prevalence of thalassemia was investigated in 101 malaria patients with Plasmodium falciparum and Plasmodium vivax along the Thai-Myanmar border to examine protective effect of thalassemia against severe malaria. Hemoglobin typing was performed using low pressure liquid chromatography (LPLC) and α-thalassemia was confirmed by multiplex PCR. Five types of thalassemia were observed in malaria patients. The 2 major types of thalassemia were Hb E (18.8%) and α-thalassemia-2 (11.9%). There was no association between thalassemia hemoglobinopathy and malaria parasitemia, an indicator of malaria disease severity. Thalassemia had no significant association with P. vivax infection, but the parasitemia in patients with coexistence of P. vivax and thalassemia was about 2-3 times lower than those with coexistence of P. falciparum and thalassemia and malaria without thalassemia. Furthermore, the parasitemia of P. vivax in patients with coexistence of Hb E showed lower value than coexistence with other types of thalassemia and malaria without coexistence. Parasitemia, hemoglobin, and hematocrit values in patients with coexistence of thalassemia other than Hb E were significantly lower than those without coexistence of thalassemia. Furthermore, parasitemia with coexistence of Hb E were 2 times lower than those with coexistence of thalassemia other than Hb E. In conclusion, the results may, at least in part, support the protective effect of thalassemia on the development of hyperparasitemia and severe anemia in malaria patients.
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