ArticleParasites & vectors2015
Bacteria-induced egg hatching differs for Trichuris muris and Trichuris suis.
Article in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Convergence in Coevolved Systems: A Two-Axis Filter for Biomimetic Transferability.Biomimetics (Basel, Switzerland) · 2026Article
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- Hatching of whipworm eggs induced by bacterial contact is serine-protease dependent.PLoS pathogens · 2025Article
- Ovicidal activity and cytotoxicity of ethanolic extract of turmeric (Open veterinary journal · 2024Article
- Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids.Advances in parasitology · 2024Article
- Detangling the Crosstalk BetweenFrontiers in cellular and infection microbiology · 2022Review
- The Influence of Genetic and Environmental Factors and Their Interactions on Immune Response to Helminth Infections.Frontiers in immunology · 2022Review
- Canine and Feline Parasitology: Analogies, Differences, and Relevance for Human Health.Clinical microbiology reviews · 2021Review
- Skin-penetrating nematodes exhibit life-stage-specific interactions with host-associated and environmental bacteria.BMC biology · 2021Article
- The interplay betweenParasitology · 2021Article
- Article
- Overview of Immunological Responses and Immunomodulation Properties ofLife (Basel, Switzerland) · 2021Review
- Pre-clinical evaluation of the effect of co-medication with antibiotics and oral steroids in Göttingen Minipigs on the biological activity of the probiotic medicinal product TSO (Trichuris suis ova).Parasitology research · 2021Article
- Whipworm-Associated Intestinal Microbiome Members Consistent Across Both Human and Mouse Hosts.Frontiers in cellular and infection microbiology · 2021Article
- Parental Microbiota Modulates Offspring Development, Body Mass and Fecundity in a Polyphagous Fruit Fly.Microorganisms · 2020Article
- Article
- Rapid environmental effects on gut nematode susceptibility in rewilded mice.PLoS biology · 2018Article
- Establishment Success of the Beetle Tapeworm Hymenolepis diminuta Depends on Dose and Host Body Condition.Insects · 2018Article
- Parasite-Microbiota Interactions With the Vertebrate Gut: Synthesis Through an Ecological Lens.Frontiers in microbiology · 2018Review
- Reciprocal Interactions between Nematodes and Their Microbial Environments.Frontiers in cellular and infection microbiology · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundEggs of the porcine whipworm Trichuris suis are currently explored in human clinical trials as a treatment of immune-mediated diseases. In this context, only the infective, embryonated eggs, constitute the Active Pharmaceutical Ingredient (API). The rodent whipworm, Trichuris muris is commonly used as a laboratory model to study Trichuris biology. The embryonated eggs (containing a fully developed larva) are biologically active and will invade the large intestinal mucosa of the host. This study aims to assess the in vitro hatching of T. muris and T. suis eggs in various bacterial cultures as a measure for their biological activity.
methodsEggs of T. muris and T. suis were incubated with Escherichia coli strain (BL-21) at three concentrations in a slightly modified in vitro egg hatching assay previously developed for T. muris. Additionally, E. coli strains (M15, SG13009, PMC103, JM109, TUNER, DH5alpha, TOP10) and five Gram-positive bacteria (Enterococcus caccae, Streptococcus hyointestinalis, Lactobacillus amylovorus, L. murinus, and L. reuteri) were tested as a hatching stimulus for T. muris and T. suis eggs.
resultsWhereas T. muris eggs hatched, T. suis did not, even when exposed to different concentrations and strains of E. coli after 4 and 24-hour incubation. When incubated with Gram-positive bacteria, only T. muris eggs showed noticeable hatching after 20 h, although with high variability.
conclusionsThe observed difference in hatching of T. muris and T. suis eggs incubated with selected bacteria, indicate significant biological differences which may reflect specific adaptation to different host-specific gut microbiota.
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