ArticlePediatric blood & cancer2015
Contribution of Sickle Cell Disease to the Pediatric Stroke Burden Among Hospital Discharges of African-Americans-United States, 1997-2012.
Article in Pediatric blood & cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Determinants of cognitive dysfunction in adults with sickle cell-related stroke or suspected neurological morbidity.Blood advances · 2024Article
- Mouse models of sickle cell disease: Imperfect and yet very informative.Blood cells, molecules & diseases · 2024Review
- Advances in the Diagnosis and Treatment of Pediatric Arterial Ischemic Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Causes and Risk Factors of Pediatric Spontaneous Intracranial Hemorrhage-A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
- Establishing a database for sickle cell disease patient mapping and survival tracking: The sickle pan-african research consortium Nigeria example.Frontiers in genetics · 2022Article
- The burden of obstructive sleep apnea in pediatric sickle cell disease: a Kids' inpatient database study.Sleep · 2021Article
- Association Between Patent Foramen Ovale and Overt Ischemic Stroke in Children With Sickle Cell Disease.Frontiers in neurology · 2021Article
- Review
- Risk Factors of Pediatric Arterial Ischemic Stroke; A Regional Survey.International journal of preventive medicine · 2018Article
- Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients.NeuroImage. Clinical · 2017Article
- Sickle Cell Disease and Stroke: Diagnosis and Management.Current neurology and neuroscience reports · 2016Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundApproximately 10-20% of children with sickle cell disease (SCD) develop stroke, but few consistent national estimates of the stroke burden for children with SCD exist. The purpose of this study is to determine the proportion of diagnosed stroke among African-American pediatric discharges with and without SCD. PROCEDURE: Records for African-Americans aged 1-18 years in the Kids' Inpatient Database (KID) 1997-2012 with ≥1 ICD-9-CM diagnosis code for stroke were included. Data were weighted to provide national estimates. A total of 2,994 stroke cases among African-American children were identified. Diagnoses co-existing with ischemic or hemorrhagic stroke were frequency ranked separately.
resultsFrom 1997 through 2012, SCD was present in 24% of stroke discharges, with 89% being ischemic stroke. For hospital discharges of African-American children, SCD is the highest co-existing risk factor for ischemic stroke (29%). Stroke in children with SCD occurred predominantly in children aged 5-9 years, older than previously reported. The trend of stroke discharges significantly decreased for children with SCD from 1997 to 2012 for children aged 10-14 years.
conclusionsSCD is a leading risk factor to pediatric stroke in African-American children. Reducing the number of strokes among children with SCD would have a significant impact on the rate of strokes among African-American children. Preventative intervention may be modifying initial age of presentation of stroke in children with SCD.
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