ReviewBritish journal of clinical pharmacology2016
Treatment of drug-induced seizures.
Review in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03310697 (Toxicological Screening by GC-MS Among Children Admitted for a First Afebrile Seizure), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Toxicological Screening by GC-MS Among Children Admitted for a First Afebrile Seizure (CASTox): a Pilot Study
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.
- The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder.Journal of addiction medicineGuideline
- Seizure-related phenomena associated with propofol: insights from the FDA Adverse Event Reporting System (FAERS).Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Neurological Complications After Pediatric Liver and Kidney Transplantation: A Comprehensive Review of Acute Symptomatic Seizures.Pediatric transplantation · 2026Review
- Article
- Molecular Docking and Simulation of Bioactive Molecules from Antiepileptic Plant Extract Presenting Significant Result in in-vivo Study.Cell biochemistry and biophysics · 2026Article
- Seizures Temporally Associated With SSRI Treatment: A Two-Case Report Exploring Agomelatine as a Treatment Alternative.Case reports in psychiatry · 2026Article
- Epidemiological Insights into Xenobiotic-Induced Seizures: A Correlational Descriptive Study from a Poisoning Referral Center in Northwestern Iran.Medical journal of the Islamic Republic of Iran · 2026Article
- Critical care management of the patient with pharmaceutical poisoning.Intensive care medicine · 2025Review
- Organophosphate Chemical Nerve Agents, Oxidative Stress, and NADPH Oxidase Inhibitors: An Overview.International journal of molecular sciences · 2025Review
- Adverse Outcome Pathway and Machine Learning to Predict Drug Induced Seizure Liability.ACS chemical neuroscience · 2025Article
- Seizure prediction in stroke survivors who experienced an infection at skilled nursing facilities-a machine learning approach.Frontiers in physiology · 2024Article
- A nomogram proposal for early prediction of intensive care unit admission in patients with acute antipsychotic poisoning.Toxicology research · 2023Article
- Point-of-Care and Dual-Response Detection of Hydrazine/Hypochlorite-Based on a Smart Hydrogel Sensor and Applications in Information Security and Bioimaging.Molecules (Basel, Switzerland) · 2023Article
- Large-scale prediction of adverse drug reactions-related proteins with network embedding.Bioinformatics (Oxford, England) · 2023Article
- Bilateral tonic seizures probably induced by eperisone hydrochloride: a case report.Frontiers in neurology · 2023Article
- Correction to: The Potential Proconvulsant Effects of Cannabis: a Scoping Review.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023Article
- Prescribing Cascades: How to Detect Them, Prevent Them, and Use Them Appropriately.Deutsches Arzteblatt international · 2022Review
- Is Seizure an Adverse Effect of Salbutamol in the Pediatric Population?Balkan medical journal · 2022Article
- The Potential Proconvulsant Effects of Cannabis: a Scoping Review.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2022Article
- Party keepers: a significant community-based intervention for harm reduction.Israel journal of health policy research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seizures are a common complication of drug intoxication, and up to 9% of status epilepticus cases are caused by a drug or poison. While the specific drugs associated with drug-induced seizures may vary by geography and change over time, common reported causes include antidepressants, stimulants and antihistamines. Seizures occur generally as a result of inadequate inhibitory influences (e.g., gamma aminobutyric acid, GABA) or excessive excitatory stimulation (e.g. glutamate) although many other neurotransmitters play a role. Most drug-induced seizures are self-limited. However, status epilepticus occurs in up to 10% of cases. Prolonged or recurrent seizures can lead to serious complications and require vigorous supportive care and anticonvulsant drugs. Benzodiazepines are generally accepted as the first line anticonvulsant therapy for drug-induced seizures. If benzodiazepines fail to halt seizures promptly, second line drugs include barbiturates and propofol. If isoniazid poisoning is a possibility, pyridoxine is given. Continuous infusion of one or more anticonvulsants may be required in refractory status epilepticus. There is no role for phenytoin in the treatment of drug-induced seizures. The potential role of ketamine and levetiracetam is promising but not established.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.