ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Transitioning from First Drug Use to Dependence Onset: Illustration of a Multiparametric Approach for Comparative Epidemiology.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Estimating the transition from alcohol drinking onset to alcohol dependence within the first year of use in the United States, 2002-2019.Journal of substance use · 2025Article
- KAlcohol (Fayetteville, N.Y.) · 2025Article
- Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice.Nature communications · 2024Article
- Article
- Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice.Biology of sex differences · 2023Article
- Delay discounting as a behavioral phenotype associated with social rank in female and male cynomolgus monkeys: Correlation with kappa opioid receptor availability.Pharmacology, biochemistry, and behavior · 2023Article
- Compulsive drug-taking is associated with habenula-frontal cortex connectivity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Sex differences in brain regional homogeneity during acute abstinence in cocaine use disorder.Addiction biology · 2022Article
- Onset of alcohol use disorder among alcohol initiates by race/ethnicity.Alcohol (Fayetteville, N.Y.) · 2021Article
- Accelerated development of cocaine-associated dopamine transients and cocaine use vulnerability following traumatic stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Female-male differences in prescription pain reliever dependence levels: Evidence on newly incident adolescent and young adult users in the United States, 2002-2014.Drug and alcohol dependence · 2019Article
- The Molecular Basis of Drug Addiction: Linking Epigenetic to Synaptic and Circuit Mechanisms.Neuron · 2019Review
- Underage drinking, alcohol dependence, and young people starting to use prescription pain relievers extra-medically: A zero-inflated Poisson regression model.Experimental and clinical psychopharmacology · 2019Article
- Sex-based differences in multidimensional clinical assessments of early-abstinence crack cocaine users.PloS one · 2019Article
- Shaping vulnerability to addiction - the contribution of behavior, neural circuits and molecular mechanisms.Neuroscience and biobehavioral reviews · 2018Review
- Estimated probability of becoming a case of drug dependence in relation to duration of drug-taking experience: a functional analysis approach.International journal of methods in psychiatric research · 2017Article
- Marijuana use disorder symptoms among recent onset marijuana users.Addictive behaviors · 2017Article
- Cannabis Epidemiology: A Selective Review.Current pharmaceutical design · 2017Review
- Inter-relationships Linking Probability of Becoming a Case of Nicotine Dependence With Frequency of Tobacco Cigarette Smoking.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
- Rapid transition from drinking to alcohol dependence among adolescent and young-adult newly incident drinkers in the United States, 2002-2013.Drug and alcohol dependence · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Studying transitions from first drug use (DU) to drug dependence (DD) onset, we estimate a parsimonious set of parameters based on epidemiological data, with plans for future longitudinal research on newly incident drug users and with tracking of self-administration frequencies and DD clinical features. Our expectation is a distinctive sigmoid pattern with one asymptote for lower DD probability (when DU is insubstantial), upturning slopes of DD risk beyond a middle value (PD50), and eventual higher DD risk asymptotes at higher DU frequencies. We illustrate this novel approach using cross-sectional data from the United States National Surveys on Drug Use and Health, 2002-2011. Empirical DD probabilities observed soon after newly incident use are estimated across DU frequency values, using parametric Hill functions and four governing parameters for differential comparison across drugs and DU subgroups. Among drug subtypes considered, cocaine shows larger estimates, especially among females (estimated P(min)=7% for females vs 3% for males; p<0.001), for whom PD50 is shorter by 8 days of use (p=0.027), conditional on the same rate of use in the past 30 days. Clear alcohol male-female differences also are observed (eg, female PD50 < male PD50; p=0.002). Although based on cross-sectional snapshots soon after DU onset, this novel multiparametric statistical approach for comparative epidemiological DD research creates new opportunities in planned studies with prospectively gathered longitudinal data. The cross-sectional estimates provide starting values needed to plan future longitudinal research programs on transitions from initial DU until formation of a DD syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.