ArticleThe journal of headache and pain2015
Validation of the Patient Health Questionnaire-9 (PHQ-9) and PHQ-2 in patients with migraine.
Article in The journal of headache and pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 3 of them syntheses that pooled it.
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Who cites it
83 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Examining the psychometric properties of brief screening measures of depression and anxiety in chronic pain: The Patient Health Questionnaire 2-item and Generalized Anxiety Disorder 2-item.Pain practice : the official journal of World Institute of Pain · 2022Pooled it
- Pooled it
- Psychological and Behavioral Issues in the Management of Migraine in Children and Adolescents.Current pain and headache reports · 2016Pooled it
- Effects of fremanezumab in patients with chronic migraine and comorbid depression: Subgroup analysis of the randomized HALO CM study.Headache · 2021Trial
- Long-Term Safety and Tolerability of OnabotulinumtoxinA Treatment in Patients with Chronic Migraine: Results of the COMPEL Study.Drug safety · 2019Trial
- Clinical and Psychosocial Predisposing Factors Associated With Anaesthesia Failure During Non-Surgical Root Canal Treatment: A National Dental Practice-Based Research Network Study.International endodontic journal · 2026Article
- Spectral Composition of Ambient White Light Modulates Photophobia and Headache Intensity During Migraine Attacks.Neurology and therapy · 2026Article
- Acculturative stress and mental health among international students in Germany: the protective roles of mindfulness, optimism, self-efficacy and coping strategies.BMC psychology · 2026Article
- Alterations of static and dynamic functional connectivity of the nucleus accumbens subregions may be associated with chronic process of migraine: a resting-state fMRI study.The journal of headache and pain · 2026Article
- Beyond accuracy: facial emotion perception bias in people with HIV in Uganda.Journal of neurovirology · 2026Article
- Sex differences in cluster headache: insights from the Chinese Cluster Headache Register Individual Study (CHRIS).The journal of headache and pain · 2026Observational
- Altered serum short-chain fatty acid profiles in episodic and chronic migraine and their modulation by preventive treatment.The journal of headache and pain · 2026Article
- A potential neuroimaging biomarker for depression in migraine patients: imbalance in excitation and inhibition in the medial superior frontal cortex.Journal of psychiatry & neuroscience : JPN · 2026Article
- Inclusive approaches to research and healthcare for nitrous oxide users: lessons from a longitudinal study.BMJ neurology open · 2026Article
- Occurrence and predictors of severe pain one week after root canal treatment: the national dental PBRN PREDICT endodontic study.Journal of dentistry · 2026Article
- Prevalence and factors associated with severe pre-operative pain among patients presenting for non-surgical root canal treatment in the national dental PBRN PREDICT endodontic study.Journal of dentistry · 2025Article
- Characteristics of teeth and patients receiving root canal treatment in National Dental PBRN practices: Comparison between Endodontist and general dentist practices.Journal of dentistry · 2025Article
- Analysis of the Prevalence of Mild Cognitive Impairment and its Influencing Factors in the Elderly Population in Huzhou City.Actas espanolas de psiquiatria · 2025Article
- Article
- Reliability and convergent validity of the PHQ-2 for the rapid detection of depressive symptoms in healthcare professionals in Argentina.Frontiers in psychiatry · 2025Article
23 more citing papers are in PubMed but not listed here.
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Abstract
backgroundPsychiatric problems have been commonly reported in patients with migraine. This study investigated the reliability and validity of the Patient Health Questionnaire-9 (PHQ-9) and Patient Health Questionnaire-9 (PHQ-2) in patients with migraine.
methodsPatients with migraine (with or without aura) were consecutively recruited from our headache clinic. They completed several instruments, including the Mini International Neuropsychiatric Interview-Plus Version 5.0.0 (MINI), the PHQ-9, the Beck Depression Inventory-II (BDI-II), the Migraine Disability Assessment Scale (MIDAS), the Headache Impact Test-6 (HIT-6), and the Migraine-Specific Quality of Life (MSQoL).
resultsAmong 132 participants, 39 patients (29.5%) had a major depressive disorder (MDD) as determined by the MINI. Cronbach's α coefficients for the PHQ-9 and PHQ-2 were 0.894 and 0.747, respectively. At a cutoff score of 7, the PHQ-9 had a sensitivity of 79.5%, a specificity of 81.7%, a positive predictive value (PPV) of 64.6%, and a negative predictive value (NPV) of 90.5%. At a cutoff score of 2, the PHQ-2 had a sensitivity of 66.7%, a specificity of 90.3%, a PPV of 74.3%, and a NPV of 86.6%. The scores of the PHQ-9 and PHQ-2 well correlated with the BDI-II score, the MIDAS score, the HIT-6 score, and the MSQoL score.
conclusionsThe PHQ-9 and PHQ-2 are both reliable and valid screening instruments for MDD in patients with migraine.
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