ArticleNeural development2015
Developmental remodeling of relay cells in the dorsal lateral geniculate nucleus in the absence of retinal input.
Article in Neural development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Article
- Retinal ganglion cell circuits and glial interactions in humans and mice.Trends in neurosciences · 2024Review
- Retinal Input Is Required for the Maintenance of Neuronal Laminae in the Ventrolateral Geniculate Nucleus.eNeuro · 2024Article
- Development of reciprocal connections between the dorsal lateral geniculate nucleus and the thalamic reticular nucleus.Neural development · 2024Article
- Microanalytical Mass Spectrometry with Super-Resolution Microscopy Reveals a Proteome Transition During Development of the Brain's Circadian Pacemaker.Analytical chemistry · 2023Article
- Article
- Pattern of Driver-Like Input onto Neurons of the Mouse Ventral Lateral Geniculate Nucleus.eNeuro · 2023Article
- The parabigeminal nucleus is a source of "retinogeniculate replacement terminals" in mice that lack retinofugal input.The Journal of comparative neurology · 2022Article
- Development of astrocyte morphology and function in mouse visual thalamus.The Journal of comparative neurology · 2022Article
- Cre driver mouse lines for thalamocortical circuit mapping.The Journal of comparative neurology · 2022Article
- Structural and Functional Plasticity in the Dorsolateral Geniculate Nucleus of Mice following Bilateral Enucleation.Neuroscience · 2022Article
- Review
- Diverse GABAergic neurons organize into subtype-specific sublaminae in the ventral lateral geniculate nucleus.Journal of neurochemistry · 2021Article
- Retinal ganglion cell interactions shape the developing mammalian visual system.Development (Cambridge, England) · 2020Review
- Synaptic properties of the feedback connections from the thalamic reticular nucleus to the dorsal lateral geniculate nucleus.Journal of neurophysiology · 2020Article
- Retinal inputs signal astrocytes to recruit interneurons into visual thalamus.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Neuronal and Synaptic Plasticity in the Visual Thalamus in Mouse Models of Glaucoma.Frontiers in cellular neuroscience · 2020Article
- Sox2 Acts in Thalamic Neurons to Control the Development of Retina-Thalamus-Cortex Connectivity.iScience · 2019Article
- Developmental Remodeling of Thalamic Interneurons Requires Retinal Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Retinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleus.Epigenetics & chromatin · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe dorsal lateral geniculate nucleus (dLGN) of the mouse has been an important experimental model for understanding thalamic circuit development. The developmental remodeling of retinal projections has been the primary focus, however much less is known about the maturation of their synaptic targets, the relay cells of the dLGN. Here we examined the growth and maturation of relay cells during the first few weeks of life and addressed whether early retinal innervation affects their development. To accomplish this we utilized the math5 null (math5 (-/-) ) mouse, a mutant lacking retinal ganglion cells and central projections.
resultsThe absence of retinogeniculate axon innervation led to an overall shrinkage of dLGN and disrupted the pattern of dendritic growth among developing relay cells. 3-D reconstructions of biocytin filled neurons from math5 (-/-) mice showed that in the absence of retinal input relay cells undergo a period of exuberant dendritic growth and branching, followed by branch elimination and an overall attenuation in dendritic field size. However, math5 (-/-) relay cells retained a sufficient degree of complexity and class specificity, as well as their basic membrane properties and spike firing characteristics.
conclusionsRetinal innervation plays an important trophic role in dLGN development. Additional support perhaps arising from non-retinal innervation and signaling is likely to contribute to the stabilization of their dendritic form and function.
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