ArticleNeuroradiology2015
Increased connectivity between sensorimotor and attentional areas in Parkinson's disease.
Article in Neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Resting-state functional reorganization in Parkinson's disease: An activation likelihood estimation meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2017Pooled it
- Dynamic functional connectivity is related to cognitive performance of prodromal Lewy body dementia.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Cortical functional hierarchy disruption following subcortical stroke.BMC medicine · 2026Article
- Intrinsic Functional Connectivity Associated with γ‑Aminobutyric Acid and Glutamate/Glutamine in the Lateral Prefrontal Cortex and Internalizing Psychopathology in Adolescents.Neuroscience bulletin · 2025Article
- Type-1 Diabetes Impacts Brain Microstructure and Anatomical Associations in Young and Well-Controlled Individuals.Brain topography · 2025Article
- Alterations in functional and structural connectivity in the 6-OHDA-induced Parkinsonian rat model.Frontiers in neuroscience · 2025Article
- Network disruption based on multi-modal EEG-MRI in α-synucleinopathies.Frontiers in neurology · 2024Article
- Effects of task prioritization on a postural-motor task in early-stage Parkinson's disease: EEG connectivity and clinical implication.GeroScience · 2022Article
- Identifying and validating subtypes of Parkinson's disease based on multimodal MRI dataFrontiers in human neuroscience · 2022Article
- Within- and across-network alterations of the sensorimotor network in Parkinson's disease.Neuroradiology · 2021Article
- The Cerebellum Is a Common Key for Visuospatial Execution and Attention in Parkinson's Disease.Diagnostics (Basel, Switzerland) · 2021Article
- Parkinson's Disease in Romania: A Scoping Review.Brain sciences · 2021Article
- Characterizing resting-state networks in Parkinson's disease: A multi-aspect functional connectivity study.Brain and behavior · 2021Article
- Functional Connectome in Parkinson's Disease and Parkinsonism.Current neurology and neuroscience reports · 2021Review
- Altered Cortical Cholinergic Network in Parkinson's Disease at Different Stage: A Resting-State fMRI Study.Frontiers in aging neuroscience · 2021Article
- Increased on-state cortico-mesencephalic functional connectivity in Parkinson disease with freezing of gait.Parkinsonism & related disorders · 2020Article
- Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease.Frontiers in neurology · 2020Article
- Machine-learning identifies Parkinson's disease patients based on resting-state between-network functional connectivity.The British journal of radiology · 2019Article
- Emergent Functional Network Effects in Parkinson Disease.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Association Between Social Cognition Changes and Resting State Functional Connectivity in Frontotemporal Dementia, Alzheimer's Disease, Parkinson's Disease, and Healthy Controls.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOur study is using Independent Component Analysis (ICA) to evaluate functional connectivity changes in Parkinson's disease (PD) in an unbiased manner.
methodsResting-state functional magnetic resonance imaging (rs-fMRI) data was collected for 27 PD patients and 16 healthy subjects. Differences for intra- and inter-network connectivity between healthy subjects and patients were investigated using FMRIB Software Library (FSL) tools (Melodic ICA, dual regression, FSLNets).
resultsTwenty-three ICA maps were identified as components of neuronal origin. For intra-network connectivity changes, eight components showed a significant connectivity increase in patients (p < 0.05); these were correlated with clinical scores and were largest for (sensori)motor networks. For inter-network connectivity changes, we found higher connectivity between the sensorimotor network and the spatial attention network (p = 0.0098) and lower connectivity between anterior and posterior default mode networks (DMN) (p = 0.024), anterior DMN and visual recognition networks (p = 0.026), as well as between visual attention and main dorsal attention networks (p = 0.03), for patients as compared to healthy subjects. The area under the Receiver Operating Characteristics (ROC) curve for the best predictor (partial correlation between sensorimotor and spatial attention networks) was 0.772. These functional alterations were not associated with any gray or white matter structural changes.
conclusionOur results show higher connectivity between sensorimotor and spatial attention areas in patients that may be related to the reduced movement automaticity in PD.
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