ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015
Vascular coupling in resting-state fMRI: evidence from multiple modalities.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Coupling between global brain blood oxygen level-dependent activity and cerebrospinal fluid dynamics in young endurance athletes.Experimental physiology · 2026Article
- Association between low-frequency oscillations in blood pressure variability and brain age derived from neuroimaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Multi-Metric Approach for the Comparison of Denoising Techniques for Resting-State fMRI.Human brain mapping · 2025Article
- Study protocol: Cerebral autoregulation, brain perfusion, and neurocognitive outcomes after traumatic brain injury -CAPCOG-TBI.Frontiers in neurology · 2024Article
- Variability in Resting-State Functional Magnetic Resonance Imaging: The Effect of Body Mass, Blood Pressure, Hematocrit, and Glycated Hemoglobin on Hemodynamic and Neuronal Parameters.Brain connectivity · 2022Article
- Mind blanking is a distinct mental state linked to a recurrent brain profile of globally positive connectivity during ongoing mentation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Resting-state functional MRI signal fluctuation amplitudes are correlated with brain amyloid-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Seed-based dual regression: An illustration of the impact of dual regression's inherent filtering of global signal.Journal of neuroscience methods · 2022Article
- Functional network antagonism and consciousness.Network neuroscience (Cambridge, Mass.) · 2022Article
- Evaluation of noise regression techniques in resting-state fMRI studies using data of 434 older adults.Frontiers in neuroscience · 2022Article
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- BOLD Coupling between Lesioned and Healthy Brain Is Associated with Glioma Patients' Recovery.Cancers · 2021Article
- Central autonomic network functional connectivity: correlation with baroreflex function and cardiovascular variability in older adults.Brain structure & function · 2020Article
- Multivariate classification of schizophrenia and its familial risk based on load-dependent attentional control brain functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Altered Gray Matter Volume and Functional Connectivity in Human Immunodeficiency Virus-Infected Adults.Frontiers in neuroscience · 2020Article
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- Cerebral blood flow in normal aging adults: cardiovascular determinants, clinical implications, and aerobic fitness.Journal of neurochemistry · 2018Review
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- Human subarachnoid space width oscillations in the resting state.Scientific reports · 2018Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Resting-state functional magnetic resonance imaging (rs-fMRI) provides a potential to understand intrinsic brain functional connectivity. However, vascular effects in rs-fMRI are still not fully understood. Through multiple modalities, we showed marked vascular signal fluctuations and high-level coupling among arterial pressure, cerebral blood flow (CBF) velocity and brain tissue oxygenation at <0.08 Hz. These similar spectral power distributions were also observed in blood oxygen level-dependent (BOLD) signals obtained from six representative regions of interest (ROIs). After applying brain global, white-matter, cerebrospinal fluid (CSF) mean signal regressions and low-pass filtering (<0.08 Hz), the spectral power of BOLD signal was reduced by 55.6% to 64.9% in all ROIs (P=0.011 to 0.001). The coherence of BOLD signal fluctuations between an ROI pair within a same brain network was reduced by 9.9% to 20.0% (P=0.004 to <0.001), but a larger reduction of 22.5% to 37.3% (P=0.032 to <0.001) for one not in a same network. Global signal regression overall had the largest impact in reducing spectral power (by 52.2% to 61.7%) and coherence, relative to the other three preprocessing steps. Collectively, these findings raise a critical question of whether a large portion of rs-fMRI signals can be attributed to the vascular effects produced from upstream changes in cerebral hemodynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.