ArticleBritish journal of anaesthesia2015
Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain.
Article in British journal of anaesthesia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Impact of aging on animal models of Parkinson's disease.Frontiers in aging neuroscience · 2022Pooled it
- Anaesthesia for pigs, sheep, goats and cattle involved in biomedical research: FELASA working group guidelines-Parts I-IV.Laboratory animals · 2026Article
- Astrocyte morphological remodeling regulates consciousness state transitions induced by inhaled general anesthesia.Molecular psychiatry · 2025Article
- NDUFA10-Mediated ATP Reduction in Medial Prefrontal Cortex Exacerbates Burst Suppression in Aged Mice.CNS neuroscience & therapeutics · 2025Article
- Article
- Electroencephalographic monitoring of anesthesia during surgical procedures in mice using a modified clinical monitoring system.Journal of clinical monitoring and computing · 2024Article
- The effect of methylphenidate on anaesthesia recovery: An experimental study in pigs.PloS one · 2024Article
- Delayed awakening and its associated factor following general anesthesia service, 2022: a cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- Anesthetic modulations dissociate neuroelectric characteristics between sensory-evoked and spontaneous activities across bilateral rat somatosensory cortical laminae.Scientific reports · 2022Article
- The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia.Frontiers in neuroscience · 2021Article
- Dopamine D1 receptor in the NAc shell is involved in delayed emergence from isoflurane anesthesia in aged mice.Brain and behavior · 2021Article
- Sleep/Wake Behavior and EEG Signatures of the TgF344-AD Rat Model at the Prodromal Stage.International journal of molecular sciences · 2020Article
- Impact of Aging on the 6-OHDA-Induced Rat Model of Parkinson's Disease.International journal of molecular sciences · 2020Article
- Deficiency of Mitochondrial Functions and Peroxidation of Frontoparietal Cortex Enhance Isoflurane Sensitivity in Aging Mice.Frontiers in aging neuroscience · 2020Article
- Dexmedetomidine and propofol sedation requirements in an autistic rat model.Korean journal of anesthesiology · 2019Article
- Alpha rhythm collapse predicts iso-electric suppressions during anesthesia.Communications biology · 2019Observational
- Isoflurane-Induced Burst Suppression Increases Intrinsic Functional Connectivity of the Monkey Brain.Frontiers in neuroscience · 2019Article
- A pilot study showing that repeated exposure to stress produces alterations in subsequent responses to anesthetics in rats.PloS one · 2019Article
- A critical review of the in vitro and in vivo models for the evaluation of anti-infective meshes.Hernia : the journal of hernias and abdominal wall surgery · 2018Review
- The plasma levels of brain-derived neurotrophic factor are positively associated with emergence agitation in the elderly after gastrointestinal surgery.Journal of anesthesia · 2016Observational
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8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLittle is known about ageing-related changes in the brain that affect emergence from general anaesthesia. We used young adult and aged Fischer 344 rats to test the hypothesis that ageing delays emergence from general anaesthesia by increasing anaesthetic sensitivity in the brain.
methodsTime to emergence was determined for isoflurane (1.5 vol% for 45 min) and propofol (8 mg kg(-1) i.v.). The dose of isoflurane required to maintain loss of righting (LOR) was established in young adult and aged rats. The efficacy of methylphenidate to reverse LOR from general anaesthesia was tested. Separate young adult and aged rats with implanted electroencephalogram (EEG) electrodes were used to test whether ageing increases sensitivity to anaesthetic-induced burst suppression.
resultsMean time to emergence from isoflurane anaesthesia was 47 s [95% CI 33, 60; young adult) compared with 243 s (95% CI 185, 308; aged). For propofol, mean time to emergence was 13.1 min (95% CI 11.9, 14.0; young adult) compared with 23.1 min (95% CI 18.8, 27.9; aged). These differences were statistically significant. When methylphenidate was administered after propofol, the mean time to emergence decreased to 6.6 min (95% CI 5.9, 7.1; young adult) and 10.2 min (95% CI 7.9, 12.3; aged). These reductions were statistically significant. Methylphenidate restored righting in all rats during continuous isoflurane anaesthesia. Aged rats had lower EEG power and were more sensitive to anaesthetic-induced burst suppression.
conclusionsAgeing delays emergence from general anaesthesia. This is due, at least in part, to increased anaesthetic sensitivity in the brain. Further studies are warranted to establish the underlying causes.
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