ArticleChemistry (Weinheim an der Bergstrasse, Germany)2015
Dynamic covalent organocatalysts discovered from catalytic systems through rapid deconvolution screening.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The Asymmetric Self-Replicative Alkylation of N-Arylaldimines Using Organolithium Reagents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- Selection between Competing Self-Reproducing Lipids: Succession and Dynamic Activation.JACS Au · 2021Article
- Dynamic Covalent Kinetic Resolution.Catalysis reviews, science and engineering · 2020Article
- Unravelling mechanistic features of organocatalysis with in situ modifications at the secondary sphere.Nature chemistry · 2019Article
- Versatile Coordination and C-C Coupling of Diphosphine-Tethered Imine Ligands with Ni(II) and Ni(0).Inorganic chemistry · 2018Article
- Resolving a Reactive Organometallic Intermediate from Dynamic Directing Group Systems by Selective C-H Activation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Dynamic Covalent Chemistry of Aldehyde Enamines: BiChemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Enzyme classification using complex dynamic hemithioacetal systems.Chemical communications (Cambridge, England) · 2016Article
Corrections and comments
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The first example of a bifunctional organocatalyst assembled through dynamic covalent chemistry (DCC) is described. The catalyst is based on reversible imine chemistry and can catalyze the Morita-Baylis-Hillman (MBH) reaction of enones with aldehydes or N-tosyl imines. Furthermore, these dynamic catalysts were shown to be optimizable through a systemic screening approach, in which large mixtures of catalyst structures were generated, and the optimal catalyst could be directly identified by using dynamic deconvolution. This strategy allowed one-pot synthesis and in situ evaluation of several potential catalysts without the need to separate, characterize, and purify each individual structure. The systems were furthermore shown to catalyze and re-equilibrate their own formation through a previously unknown thiourea-catalyzed transimination process.
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