ArticleHeredity2016
Genetic variance components and heritability of multiallelic heterozygosity under inbreeding.
Article in Heredity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis.Communications biology · 2023Pooled it
- Is there an advantage of using genomic information to estimate gametic variances and improve recurrent selection in animal populations?Genetics, selection, evolution : GSE · 2025Article
- Secrets and lies of host-microbial interactions: MHC restriction and trans-regulation of T cell trafficking conceal the role of microbial agents on the edge between health and multifactorial/complex diseases.Cellular and molecular life sciences : CMLS · 2024Review
- Evolutionary transitions in heritability and individuality.Theory in biosciences = Theorie in den Biowissenschaften · 2019Article
- Drivers of sex ratio bias in the eastern bongo: lower inbreeding increases the probability of being born male.Proceedings. Biological sciences · 2019Article
- Population genomics and morphometric assignment of western honey bees (Apis mellifera L.) in the Republic of South Africa.BMC genomics · 2018Article
- Feed-backs among inbreeding, inbreeding depression in sperm traits, and sperm competition can drive evolution of costly polyandry.Evolution; international journal of organic evolution · 2017Article
- A father effect explains sex-ratio bias.Proceedings. Biological sciences · 2017Article
- Application of single step genomic BLUP under different uncertain paternity scenarios using simulated data.PloS one · 2017Article
- 'Out of tune': consequences of inbreeding on bird song.Proceedings. Biological sciences · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The maintenance of genetic diversity in fitness-related traits remains a central topic in evolutionary biology, for example, in the context of sexual selection for genetic benefits. Among the solutions that have been proposed is directional sexual selection for heterozygosity. The importance of such selection is highly debated. However, a critical evaluation requires knowledge of the heritability of heterozygosity, a quantity that is rarely estimated in this context, and often assumed to be zero. This is at least partly the result of the lack of a general framework that allows for its quantitative prediction in small and inbred populations, which are the focus of most empirical studies. Moreover, while current predictors are applicable only to biallelic loci, fitness-relevant loci are often multiallelic, as are the neutral markers typically used to estimate genome-wide heterozygosity. To this end, we first review previous, but little-known, work showing that under most circumstances, heterozygosity at biallelic loci and in the absence of inbreeding is heritable. We then derive the heritability of heterozygosity and the underlying variances for multiple alleles and any inbreeding level. We also show that heterozygosity at multiallelic loci can be highly heritable when allele frequencies are unequal, and that this heritability is reduced by inbreeding. Our quantitative genetic framework can provide new insights into the evolutionary dynamics of heterozygosity in inbred and outbred populations.
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