ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2016
Accurate analysis and visualization of cardiac (11)C-PIB uptake in amyloidosis with semiautomatic software.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The flutemetamol analogue cyano-flutemetamol detects myocardial AL and ATTR amyloid deposits: a post-mortem histofluorescence analysis.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis · 2023Article
- Reproducibility and Repeatability of Assessment of Myocardial Light Chain Amyloidosis Burden UsingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation (4Is)-related cardiovascular diseases: a joint collaboration of the EACVI and the EANM.European journal of nuclear medicine and molecular imaging · 2021Article
- Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation- (4Is) related cardiovascular diseases: a joint collaboration of the EACVI and the EANM: summary.European heart journal. Cardiovascular Imaging · 2020Article
- Multimodality Imaging in the Evaluation and Management of Cardiac Amyloidosis.Seminars in nuclear medicine · 2020Review
- Quantification ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Expert Consensus Recommendations for the Suspicion and Diagnosis of Transthyretin Cardiac Amyloidosis.Circulation. Heart failure · 2019Review
- ExtracardiacEuropean journal of nuclear medicine and molecular imaging · 2018Article
- Positron emission tomography (PET) utilizing Pittsburgh compound B (PIB) for detection of amyloid heart deposits in hereditary transthyretin amyloidosis (ATTR).Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Nuclear imaging of cardiac amyloidosis. 'We've only just begun'.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Review of Cardiovascular Imaging in the Journal of Nuclear Cardiology in 2016. Part 1 of 2: Positron Emission Tomography, Computed Tomography and Magnetic Resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Review
- Role of imaging in cardiac amyloidosis: An ongoing challenge.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Quantitative molecular imaging of cardiac amyloidosis: The journey has begun.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Review of cardiovascular imaging in the journal of nuclear cardiology in 2015. Part 1 of 2: Plaque imaging, positron emission tomography, computed tomography, and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Review
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background(11)C-PIB PET is a promising non-invasive diagnostic tool for cardiac amyloidosis. Semiautomatic analysis of PET data is now available but it is not known how accurate these methods are for amyloid imaging. The aim of this study was to evaluate the feasibility of one semiautomatic software tool for analysis and visualization of (11)C-PIB left ventricular retention index (RI) in cardiac amyloidosis. METHODS AND
resultsPatients with systemic amyloidosis and cardiac involvement (n = 10) and healthy controls (n = 5) were investigated with dynamic (11)C-PIB PET. Two observers analyzed the PET studies with semiautomatic software to calculate the left ventricular RI of (11)C-PIB and to create parametric images. The mean RI at 15-25 min from the semiautomatic analysis was compared with RI based on manual analysis and showed comparable values (0.056 vs 0.054 min(-1) for amyloidosis patients and 0.024 vs 0.025 min(-1) in healthy controls; P = .78) and the correlation was excellent (r = 0.98). Inter-reader reproducibility also was excellent (intraclass correlation coefficient, ICC > 0.98). Parametric polarmaps and histograms made visual separation of amyloidosis patients and healthy controls fast and simple.
conclusionAccurate semiautomatic analysis of cardiac (11)C-PIB RI in amyloidosis patients is feasible. Parametric polarmaps and histograms make visual interpretation fast and simple.
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