ReviewIntegrative and comparative biology2015
DNA Methylation in Basal Metazoans: Insights from Ctenophores.
Review in Integrative and comparative biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Hydra at the Crossroads of Evolution: Insights into Cell-type Diversification, Regeneration, and Epigenetic Regulation.Results and problems in cell differentiation · 2026Review
- Genome-wide DNA methylation patterns in Daphnia magna are not significantly associated with age.Epigenetics & chromatin · 2025Article
- MyD88 inhibitor TJ-M2010-5 alleviates spleen impairment and inflammation by inhibiting the PI3K/miR-136-5p/AKT3 pathway in the early infection of Trichinella spiralis.Veterinary research · 2025Article
- Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates?Frontiers in genetics · 2025Article
- DNA Methylation Machinery in Gastropod Mollusks.Life (Basel, Switzerland) · 2024Review
- DNA Methylation in Ctenophores.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Nitric oxide suppresses cilia activity in ctenophores.bioRxiv : the preprint server for biology · 2023Article
- Recording cilia activity in ctenophores: effects of nitric oxide and low molecular weight transmitters.Frontiers in neuroscience · 2023Article
- A Broad Survey of Gene Body and Repeat Methylation in Cnidaria Reveals a Complex Evolutionary History.Genome biology and evolution · 2022Article
- Evolution of Methyltransferase-Like (METTL) Proteins in Metazoa: A Complex Gene Family Involved in Epitranscriptomic Regulation and Other Epigenetic Processes.Molecular biology and evolution · 2021Article
- DNA methylation atlas and machinery in the developing and regenerating annelid Platynereis dumerilii.BMC biology · 2021Article
- Myxosporea (Myxozoa, Cnidaria) Lack DNA Cytosine Methylation.Molecular biology and evolution · 2021Article
- Epigenetic Regulation inFrontiers in cell and developmental biology · 2021Review
- Detection of NAdvances in experimental medicine and biology · 2021Article
- The Methyl-CpG-Binding Domain 2 and 3 Proteins and Formation of the Nucleosome Remodeling and Deacetylase Complex.Journal of molecular biology · 2020Review
- Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis.National science review · 2019Article
- Article
- DNA methylation in adults and during development of the self-fertilizing mangrove rivulus,Ecology and evolution · 2018Article
- Notos - a galaxy tool to analyze CpN observed expected ratios for inferring DNA methylation types.BMC bioinformatics · 2018Article
- Food availability drives plastic self-repair response in a basal metazoan- case study on the ctenophore Mnemiopsis leidyi A. Agassiz 1865.Scientific reports · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
Epigenetic modifications control gene expression without altering the primary DNA sequence. However, little is known about DNA methylation in invertebrates and its evolution. Here, we characterize two types of genomic DNA methylation in ctenophores, 5-methyl cytosine (5-mC) and the unconventional form of methylation 6-methyl adenine (6-mA). Using both bisulfite sequencing and an ELISA-based colorimetric assay, we experimentally confirmed the presence of 5-mC DNA methylation in ctenophores. In contrast to other invertebrates studied, Mnemiopsis leidyi has lower levels of genome-wide 5-mC methylation, but higher levels of 5-mC methylation in promoters when compared with gene bodies. Phylogenetic analysis showed that ctenophores have distinct forms of DNA methyltransferase 1 (DNMT1); the zf-CXXC domain type, which localized DNMT1 to CpG sites, and is a metazoan specific innovation. We also show that ctenophores encode the full repertoire of putative enzymes for 6-mA DNA methylation, and these genes are expressed in the aboral organ of Mnemiopsis. Using an ELISA-based colorimetric assay, we experimentally confirmed the presence of 6-mA methylation in the genomes of three different species of ctenophores, M. leidyi, Beroe abyssicola, and Pleurobrachia bachei. The functional role of this novel epigenomic mark is currently unknown. In summary, despite their compact genomes, there is a wide variety of epigenomic mechanisms employed by basal metazoans that provide novel insights into the evolutionary origins of biological novelties.
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