ArticleMagnetic resonance in medicine2016
pH imaging of mouse kidneys in vivo using a frequency-dependent paraCEST agent.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Detection of tissue pH with quantitative chemical exchange saturation transfer magnetic resonance imaging.NMR in biomedicine · 2023Review
- Noninvasive assessment of renal dynamics and pH in a unilateral ureter obstruction model using DCE MR-CEST urography.Magnetic resonance in medicine · 2023Article
- Detection of glucose-derived D- and L-lactate in cancer cells by the use of a chiral NMR shift reagent.Cancer & metabolism · 2021Article
- Quasi-steady-state chemical exchange saturation transfer (QUASS CEST) MRI analysis enables TJournal of magnetic resonance (San Diego, Calif. : 1997) · 2021Article
- Quasi-steady state chemical exchange saturation transfer (QUASS CEST) analysis-correction of the finite relaxation delay and saturation time for robust CEST measurement.Magnetic resonance in medicine · 2021Article
- Dynamic Contrast Enhanced-MR CEST Urography: An Emerging Tool in the Diagnosis and Management of Upper Urinary Tract Obstruction.Tomography (Ann Arbor, Mich.) · 2021Review
- A fast multislice sequence for 3D MRI-CEST pH imaging.Magnetic resonance in medicine · 2021Article
- Lanthanide(III) Complexes Based on an 18-Membered Macrocycle Containing Acetamide Pendants. Structural Characterization and paraCEST Properties.Inorganic chemistry · 2021Article
- Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept.Methods in molecular biology (Clifton, N.J.) · 2021Article
- A Frequency-Selective pH-Responsive paraCEST Agent.Angewandte Chemie (International ed. in English) · 2020Article
- CEST MR-Fingerprinting: Practical considerations and insights for acquisition schedule design and improved reconstruction.Magnetic resonance in medicine · 2020Article
- Assessments of tumor metabolism with CEST MRI.NMR in biomedicine · 2019Review
- Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging.Science advances · 2019Article
- Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH.Cancer metastasis reviews · 2019Review
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
- A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol.Magnetic resonance in medicine · 2018Article
- Lanthanide-Based TAngewandte Chemie (International ed. in English) · 2017Article
- Multislice CEST MRI improves the spatial assessment of tumor pH.Magnetic resonance in medicine · 2017Article
- Cancer Metabolism and Tumor Heterogeneity: Imaging Perspectives Using MR Imaging and Spectroscopy.Contrast media & molecular imaging · 2017Review
- Gear Up for a pH Shift: A Responsive Iron(II) 2-Amino-6-picolyl-Appended Macrocyclic paraCEST Agent That Protonates at a Pendent Group.Inorganic chemistry · 2016Article
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7 authors.
Funding
Abstract
purposeThis study explored the feasibility of using a pH responsive paramagnetic chemical exchange saturation transfer (paraCEST) agent to image the pH gradient in kidneys of healthy mice.
methodsCEST signals were acquired on an Agilent 9.4 Tesla small animal MRI system using a steady-state gradient echo pulse sequence after a bolus injection of agent. The magnetic field inhomogeneity across each kidney was corrected using the WASSR method and pH maps were calculated by measuring the frequency of water exchange signal arising from the agent.
resultsDynamic CEST studies demonstrated that the agent was readily detectable in kidneys only between 4 to 12 min postinjection. The CEST images showed a higher signal intensity in the pelvis and calyx regions and lower signal intensity in the medulla and cortex regions. The pH maps reflected tissue pH values spanning from 6.0 to 7.5 in kidneys of healthy mice.
conclusionThis study demonstrated that pH maps of the kidney can be imaged in vivo by measuring the pH-dependent chemical shift of a single water exchange CEST peak without prior knowledge of the agent concentration in vivo. The results demonstrate the potential of using a simple frequency-dependent paraCEST agent for mapping tissue pH in vivo. Magn Reson Med 75:2432-2441, 2016. © 2015 Wiley Periodicals, Inc.
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