ArticlePsychopharmacology2015
Evidence for the involvement of NMDA receptors in the antidepressant-like effect of nicotine in mouse forced swimming and tail suspension tests.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
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- Mediation of the behavioral effects of ketamine and (2R,6R)-hydroxynorketamine in mice by kappa opioid receptors.Psychopharmacology · 2022Article
- Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor.Frontiers in pharmacology · 2022Article
- Molecular Targets of Cannabinoids Associated with Depression.Current medicinal chemistry · 2022Review
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- The cholinesterase inhibitor donepezil has antidepressant-like properties in the mouse forced swim test.Translational psychiatry · 2020Article
- Ketamine relieves depression-like behaviors induced by chronic postsurgical pain in rats through anti-inflammatory, anti-oxidant effects and regulating BDNF expression.Psychopharmacology · 2020Article
- Repurposing Cholinesterase Inhibitors as Antidepressants? Dose and Stress-Sensitivity May Be Critical to Opening Possibilities.Frontiers in behavioral neuroscience · 2020Review
- Evaluation and comparison of the antidepressant-like activity ofResearch in pharmaceutical sciences · 2019Article
- NMDA receptors and L-arginine/nitric oxide/cyclic guanosine monophosphate pathway contribute to the antidepressant-like effect of Yueju pill in mice.Bioscience reports · 2019Article
- Evaluation of the pharmacological involvement of ATP-sensitive potassium (KNaunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics.Molecular psychiatry · 2019Review
- Sustained antidepressant action of the N-methyl-D-aspartate receptor antagonist MK-801 in a chronic unpredictable mild stress model.Experimental and therapeutic medicine · 2018Article
- Nicotine Significantly Improves Chronic Stress-Induced Impairments of Cognition and Synaptic Plasticity in Mice.Molecular neurobiology · 2017Article
- Alterations in the inflammatory cytokines and brain-derived neurotrophic factor contribute to depression-like phenotype after spared nerve injury: improvement by ketamine.Scientific reports · 2017Article
- Nicotine Elicits Convulsive Seizures by Activating Amygdalar Neurons.Frontiers in pharmacology · 2017Article
- Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model.The international journal of neuropsychopharmacology · 2016Article
- Involvement of NO/cGMP pathway in the antidepressant-like effect of gabapentin in mouse forced swimming test.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- A systematic review of studies investigating the acute effects ofBrain and neuroscience advancesReview
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe antidepressant action of acute nicotine administration in clinical and animal studies is well recognized. But the underlying mechanism for this effect has not been carefully discovered.
objectivesWe attempted to evaluate the possible role of N-Methyl-D-aspartate (NMDA) receptors in the antidepressant-like effect of nicotine.
methodsAfter the assessment of locomotor activity in the open-field test, forced swimming test (FST) and tail suspension test (TST) were used to evaluate the antidepressant-like effect of nicotine in mice. We performed intraperitoneal administration of nicotine at different doses and periods before the tests. To assess the possible involvement of NMDA receptors, non-effective doses of NMDA antagonists and an NMDA agonist were obtained and were administered simultaneously with the non-effective and effective doses of nicotine, respectively.
resultsNicotine (0.2 mg/kg, 30 min before FST/TST) significantly reduced the immobility time of mice similar to fluoxetine (20 mg/kg). Nicotine did not affect the locomotor behavior of mice in open-field test. Co-administration of non-effective doses of NMDA receptor antagonists, ketamine (1 or 0.3 mg/kg), MK-801 (0.05 or 0.005 mg/kg), and magnesium sulfate (10 or 5 mg/kg) with nicotine (0.1 or 0.03 mg/kg) had remarkable synergistic antidepressant effect in both FST and TST. Also, non-effective NMDA (75 or 30 mg/kg) reversed the anti-immobility effect of nicotine (0.2 mg/kg) on mouse FST and TST.
conclusionsOur study has for the first time confirmed that the antidepressant-like effect of nicotine on mice is NMDA-mediated, and nicotine presumably exerts this effect by antagonizing the glutamatergic NMDA receptors.
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